A Prospective, Multicenter, Single-arm MAC-PD Cohort: a NTM-NET and ESGMYC Collaborative Study

Description

To gain insight in the effectiveness of, adherence and adjustments to guideline-based three-drug antimycobacterial therapy in patients with Mycobacterium avium complex pulmonary disease (MAC-PD) during the first 6 months of treatment.

Conditions

Mycobacterium Avium Complex Pulmonary Disease

Study Overview

Study Details

Study overview

To gain insight in the effectiveness of, adherence and adjustments to guideline-based three-drug antimycobacterial therapy in patients with Mycobacterium avium complex pulmonary disease (MAC-PD) during the first 6 months of treatment.

A Prospective, Multicenter, Single-arm MAC-PD Cohort: a NTM-NET and ESGMYC Collaborative Study

A Prospective, Multicenter, Single-arm MAC-PD Cohort: a NTM-NET and ESGMYC Collaborative Study

Condition
Mycobacterium Avium Complex Pulmonary Disease
Intervention / Treatment

-

Contacts and Locations

Portland

Oregon Science and Health University, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Newly diagnosed MAC-PD (primary or recurrent) as per the international NTM guideline that requires three-drug antimycobacterial treatment
  • * Signed and dated informed consent
  • * The participant is in poor general condition where participation in the study cannot be accepted per discretion of the Investigator
  • * The participant has a known or suspected, current drug or alcohol abuse, that is, in the opinion of the Investigator, sufficient to compromise the safety or cooperation of the patient
  • * HIV-infection;
  • * Cystic fibrosis;
  • * \>1 month antibiotic treatment for current MAC infection;
  • * \< 6 months between previous antimycobacterial NTM-PD treatment and antimycobacterial treatment for current MAC-PD
  • * Disseminated MAC infection;
  • * Active pulmonary tuberculosis, fungal or nocardial disease requiring treatment;
  • * Active pulmonary malignancy (primary or metastatic) or any other malignancy requiring chemotherapy or radiotherapy within 6 months before screening or anticipated during the study period;

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Radboud University Medical Center,

Jakko van Ingen, MSc, PhD, PRINCIPAL_INVESTIGATOR, Radboud University Medical Center

Study Record Dates

2026-07-01