RECRUITING

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.

Official Title

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

Quick Facts

Study Start:2024-06-24
Study Completion:2029-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05907629

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Enrollment in the CAPTIVA trial: nondisabling symptomatic ischemic infarct stroke within 30 days secondary to 70-99% stenosis of the intracranial ICA, MCA, BA or VA
  2. * Ability to obtain baseline study MRI within 14 days of CAPTIVA enrollmen
  1. * Unable or unwilling to undergo MRI, including pacemaker or other MRI contraindications per American College of Radiology guidelines62
  2. * Gadolinium contrast allergy or acute or chronic kidney disease with eGFR\<30 ml/min/1.73m2

Contacts and Locations

Study Contact

Adam H. de Havenon, MD
CONTACT
203-785-4085
adam.dehavenon@yale.edu
Ka-Ho Wong, MBA
CONTACT
801-585-7575
ka-ho.wong@hsc.utah.edu

Principal Investigator

David Liebeskind, MD
PRINCIPAL_INVESTIGATOR
University of California, Los Angeles
Sepideh Amin-Hanjani, MD
PRINCIPAL_INVESTIGATOR
University Hospitals
Rano Chatterjee, MD
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine

Study Locations (Sites)

University of Alabama Hospital
Birmingham, Alabama, 35233
United States
Baptist Medical Center Jacksonville
Jacksonville, Florida, 32207
United States
Jackson Memorial Hospital, Miami
Miami, Florida, 33136
United States
University of Illinois Hospital
Chicago, Illinois, 60612
United States
University of Chicago Medical Center
Chicago, Illinois, 60637
United States
Barnes Jewish Hospital
Saint Louis, Missouri, 63108
United States
Buffalo General Medical Center
Buffalo, New York, 14203
United States
North Shore University Hospita
Manhasset, New York, 11030
United States

Collaborators and Investigators

Sponsor: Yale University

  • David Liebeskind, MD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles
  • Sepideh Amin-Hanjani, MD, PRINCIPAL_INVESTIGATOR, University Hospitals
  • Rano Chatterjee, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-24
Study Completion Date2029-03-31

Study Record Updates

Study Start Date2024-06-24
Study Completion Date2029-03-31

Terms related to this study

Keywords Provided by Researchers

  • MRI
  • Stroke
  • intracranial atherosclerotic stenosis (ICAS)

Additional Relevant MeSH Terms

  • Stroke
  • Intracranial Atherosclerotic Stenosis (ICAS)