Treatment With Endovascular Intervention for STroke Patients With Existing Disability

Description

TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.

Conditions

Stroke, Stroke, Acute, Stroke, Ischemic

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Study Overview

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Study Details

Study overview

TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Phoenix

HonorHealth, Phoenix, Arizona, United States, 85013

Los Angeles

University of California at Los Angeles, Los Angeles, California, United States, 90095

Hartford

Hartford Health Hospital, Hartford, Connecticut, United States, 06106

New Haven

Yale University, New Haven, Connecticut, United States, 06510

Miami

University of Miami, Miami, Florida, United States, 33125

New York

Icahn School of Medicine at Mount Sinai, New York, New York, United States, 10029

New York

Columbia University, New York, New York, United States, 10032

Cincinnati

University of Cincinnati Medical Center, Cincinnati, Ohio, United States, 45219

Pittsburgh

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States, 15213

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Adult patients (≥18 years)
  • 2. Moderate-to-severe pre-stroke functional disability, defined as mRS 3-4, for at least 3 months prior to stroke onset
  • 3. Presenting to study hospital within 24 hours of last known well time
  • 4. Diagnosis of acute ischemic stroke
  • 5. Intracranial causative occlusion of the internal carotid artery or the M1 or dominant M2 segments of the middle cerebral artery visualized on the baseline CT(or MR) angiogram
  • 6. Presenting CT Alberta Stroke Program Early CT (ASPECT) score ≥3 or MRI ASPECT score ≥4
  • 7. Presenting NIH Stroke Scale score ≥6
  • 8. Informed consent from patient if competent or from legally authorized representative
  • 1. Known diagnosis of a terminal cancer or terminal illness at the time of stroke
  • 2. Assessment of pre-stroke functional status cannot be performed during the hospital stay
  • 3. Pre-stroke disability deemed temporary in the investigator's opinion (for example, recovering from a general medical illness or traumatic bodily injury)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Cincinnati,

Eva Mistry, MD, PRINCIPAL_INVESTIGATOR, University of Cincinnati

Jeffrey Saver, MD, PRINCIPAL_INVESTIGATOR, Ronald Reagan UCLA Medical Center

J Mocco, MD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Heidi Sucharew, PhD, PRINCIPAL_INVESTIGATOR, University of Cincinnati

Study Record Dates

2028-04-15