Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

Description

The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.

Conditions

Anosmia, Skull Base Neoplasms

Study Overview

Study Details

Study overview

The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

Condition
Anosmia
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins Medicine, Baltimore, Maryland, United States, 21224

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English Speaking
  • * preoperative diagnosis of benign sellar or parasellar skull base pathology
  • * preoperative diagnosis of malignant sellar or parasellar skull base pathology
  • * history of endoscopic sinus surgery
  • * history of skull base surgery
  • * history of radiation therapy or other local treatments for the management of facial, sinonasal, or cranial pathologies
  • * history of chronic rhinosinusitis
  • * history of neurocognitive disorder
  • * history of intrinsic chemosensory pathology
  • * history of cardiac pacemaker
  • * history of gastrectomy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Nicholas Rowan, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins School of Medicine

Study Record Dates

2026-01-01