ACTIVE_NOT_RECRUITING

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.

Official Title

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

Quick Facts

Study Start:2023-02-01
Study Completion:2026-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05912881

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * English Speaking
  2. * preoperative diagnosis of benign sellar or parasellar skull base pathology
  1. * preoperative diagnosis of malignant sellar or parasellar skull base pathology
  2. * history of endoscopic sinus surgery
  3. * history of skull base surgery
  4. * history of radiation therapy or other local treatments for the management of facial, sinonasal, or cranial pathologies
  5. * history of chronic rhinosinusitis
  6. * history of neurocognitive disorder
  7. * history of intrinsic chemosensory pathology
  8. * history of cardiac pacemaker
  9. * history of gastrectomy

Contacts and Locations

Principal Investigator

Nicholas Rowan, MD
PRINCIPAL_INVESTIGATOR
Johns Hopkins School of Medicine

Study Locations (Sites)

Johns Hopkins Medicine
Baltimore, Maryland, 21224
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Nicholas Rowan, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-02-01
Study Completion Date2026-01-01

Study Record Updates

Study Start Date2023-02-01
Study Completion Date2026-01-01

Terms related to this study

Additional Relevant MeSH Terms

  • Anosmia
  • Skull Base Neoplasms