Combined Respiratory Training in Persons with ALS

Description

The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1. Determine the impact of combined LVR and EMST on cough strength and respiratory function in individuals with ALS. 2. Determine the impact of combined LVR and EMST on patient-reported dyspnea and bulbar impairment. 3. Describe the effect of combined LVR and EMST on patient- and caregiver reported burden and quality of life.

Conditions

ALS, Respiratory Insufficiency, Dysphagia

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Study Overview

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Study Details

Study overview

The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1. Determine the impact of combined LVR and EMST on cough strength and respiratory function in individuals with ALS. 2. Determine the impact of combined LVR and EMST on patient-reported dyspnea and bulbar impairment. 3. Describe the effect of combined LVR and EMST on patient- and caregiver reported burden and quality of life.

Combined Respiratory Training to Improve Pulmonary and Cough Function in Persons with ALS

Combined Respiratory Training in Persons with ALS

Condition
ALS
Intervention / Treatment

-

Contacts and Locations

Fort Lauderdale

Nova Southeastern University, Fort Lauderdale, Florida, United States, 33314

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. A diagnosis of probable or definite ALS in accordance with the Revisited El-Escorial Criteria.
  • 2. Disease duration from symptom onset of ≤ 2 years,
  • 3. Lung volume recruitment and expiratory muscle strength training naïve,
  • 4. Reduced peak cough flow (% predicted for age and gender).
  • 1. History of stroke, head and neck cancer or other concomitant disorder that might contribute to dysphagia or respiratory impairment.
  • 2. Use of prescription cough assist or non-invasive volume ventilation devices.
  • 3. Enrollment in another research investigation that might impact cough or respiratory function.
  • 4. Diagnosis of frontotemporal dementia or advanced cognitive impairment.
  • 5. Tracheostomy placement/Use of invasive mechanical ventilation.
  • 6. Contraindications for respiratory training (i.e., history of pneumothorax, severe chronic obstructive pulmonary disease).

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Nova Southeastern University,

Magalie Thomas, MBA, STUDY_CHAIR, Nova Southeastern University

Study Record Dates

2026-09-30