COMPLETED

Upper Limb-based Movement Priming for Lower Limb Neuroplasticity & Motor Recovery in Stroke

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to to determine the effect of movement-based priming using the upper limbs on lower limb neuroplasticity and behaviors in chronic stroke. The main questions we aim to answer are: 1. What are the acute effect of UL-priming on lower limb neuroplasticity and motor behaviors in persons with stroke compared to other priming modalities? 2. What are the time effects of UL-priming on neuroplasticity and motor behavior in individuals with stroke? In this cross over study, participants will be involved in three priming sessions involving - UL-priming using rhythmic, symmetric, bilateral priming involving the movement of at least one major joint in the upper limbs. AND - Sham priming using auditory stimulation (1 Hz metronome). AND - Lower-limb movement-based priming using rhythmic, symmetric, dorsiflexion and plantarflexion movements. Researchers will compare outcome measures between the different priming sessions.

Official Title

Upper Limb-based Movement Priming for Lower Limb Neuroplasticity & Motor Recovery in Stroke

Quick Facts

Study Start:2024-07-01
Study Completion:2025-06-25
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05919043

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Single, monohemispheric stroke
  2. * Chronic stroke (\> 6 months prior)
  3. * Residual hemiparetic gait deficits (e.g., abnormal gait pattern)
  4. * Minimum score of stage 2 on the Chedoke Arm Impairment Scale which includes stage 2, task 3 (facilitated elbow flexion) as one of the stage 2 tasks.
  1. * Use of anti-spasticity medications
  2. * Existence of other neurological disorders
  3. * Have brainstem or cerebellar lesions.
  4. * Score of ≥2 on the Modified Ashworth Scale.
  5. * MMSE score of \<21, to ensure they will follow instructions.
  6. * Non-English-speaking individuals
  7. * Bone, joint or soft tissue injury
  8. * Uncontrolled medical conditions (such as uncontrolled hypertension, untreated cardiac disease, or untreated pulmonary disease)
  9. * No Motor evoked potentials (MEPs) during TMS
  10. * Previous adverse reaction to TMS
  11. * Skull abnormalities or fractures
  12. * Concussion within the prior 6 months
  13. * Unexplained, recurring headaches
  14. * Implanted cardiac pacemaker
  15. * Metal implants in the head or face
  16. * History of seizures or epilepsy
  17. * Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants)
  18. * Current pregnancy

Contacts and Locations

Principal Investigator

Sangeetha Madhavan, PT, PhD
PRINCIPAL_INVESTIGATOR
University of Illinois at Chicago

Study Locations (Sites)

Brain Plasticity Lab
Chicago, Illinois, 60612
United States

Collaborators and Investigators

Sponsor: University of Illinois at Chicago

  • Sangeetha Madhavan, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Illinois at Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-01
Study Completion Date2025-06-25

Study Record Updates

Study Start Date2024-07-01
Study Completion Date2025-06-25

Terms related to this study

Additional Relevant MeSH Terms

  • Stroke