Upper Limb-based Movement Priming for Lower Limb Neuroplasticity & Motor Recovery in Stroke

Description

The goal of this clinical trial is to to determine the effect of movement-based priming using the upper limbs on lower limb neuroplasticity and behaviors in chronic stroke. The main questions we aim to answer are: 1. What are the acute effect of UL-priming on lower limb neuroplasticity and motor behaviors in persons with stroke compared to other priming modalities? 2. What are the time effects of UL-priming on neuroplasticity and motor behavior in individuals with stroke? In this cross over study, participants will be involved in three priming sessions involving - UL-priming using rhythmic, symmetric, bilateral priming involving the movement of at least one major joint in the upper limbs. AND - Sham priming using auditory stimulation (1 Hz metronome). AND - Lower-limb movement-based priming using rhythmic, symmetric, dorsiflexion and plantarflexion movements. Researchers will compare outcome measures between the different priming sessions.

Conditions

Stroke

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to to determine the effect of movement-based priming using the upper limbs on lower limb neuroplasticity and behaviors in chronic stroke. The main questions we aim to answer are: 1. What are the acute effect of UL-priming on lower limb neuroplasticity and motor behaviors in persons with stroke compared to other priming modalities? 2. What are the time effects of UL-priming on neuroplasticity and motor behavior in individuals with stroke? In this cross over study, participants will be involved in three priming sessions involving - UL-priming using rhythmic, symmetric, bilateral priming involving the movement of at least one major joint in the upper limbs. AND - Sham priming using auditory stimulation (1 Hz metronome). AND - Lower-limb movement-based priming using rhythmic, symmetric, dorsiflexion and plantarflexion movements. Researchers will compare outcome measures between the different priming sessions.

Upper Limb-based Movement Priming for Lower Limb Neuroplasticity & Motor Recovery in Stroke

Upper Limb-based Movement Priming for Lower Limb Neuroplasticity & Motor Recovery in Stroke

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Chicago

Brain Plasticity Lab, Chicago, Illinois, United States, 60612

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Single, monohemispheric stroke
  • * Chronic stroke (\> 6 months prior)
  • * Residual hemiparetic gait deficits (e.g., abnormal gait pattern)
  • * Minimum score of stage 2 on the Chedoke Arm Impairment Scale which includes stage 2, task 3 (facilitated elbow flexion) as one of the stage 2 tasks.
  • * Use of anti-spasticity medications
  • * Existence of other neurological disorders
  • * Have brainstem or cerebellar lesions.
  • * Score of ≥2 on the Modified Ashworth Scale.
  • * MMSE score of \<21, to ensure they will follow instructions.
  • * Non-English-speaking individuals
  • * Bone, joint or soft tissue injury
  • * Uncontrolled medical conditions (such as uncontrolled hypertension, untreated cardiac disease, or untreated pulmonary disease)
  • * No Motor evoked potentials (MEPs) during TMS
  • * Previous adverse reaction to TMS
  • * Skull abnormalities or fractures
  • * Concussion within the prior 6 months
  • * Unexplained, recurring headaches
  • * Implanted cardiac pacemaker
  • * Metal implants in the head or face
  • * History of seizures or epilepsy
  • * Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants)
  • * Current pregnancy

Ages Eligible for Study

40 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Illinois at Chicago,

Sangeetha Madhavan, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Illinois at Chicago

Study Record Dates

2026-12