RECRUITING

Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600mg or placebo by mouth with water 1 hour prior to extraction and bone graft surgery. The primary question it aims to answer is: • Does preemptive ibuprofen have an effect on postoperative pain 1 hour following extraction and bone graft surgery compared to placebo? Secondary questions are: * Does preemptive ibuprofen have an effect on pain during the first 3 postoperative hours and 7 postoperative days following extraction and bone graft surgery compared to placebo? * Does preemptive ibuprofen have an effect on oral health-related quality of life during the 7 postoperative days following extraction and bone graft surgery compared to placebo?

Official Title

Patient Perception of Pain Following Extraction and Bone Graft Surgery With or Without Preemptive Ibuprofen: A Randomized Clinical Trial

Quick Facts

Study Start:2023-10-19
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05919745

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Vrisiis Kofina, DDS, MS
CONTACT
516-817-0393
vrisiis.kofina@marquette.edu
Christos Gousias, DDS
CONTACT
414-229-8875
christos.gousias@marquette.edu

Principal Investigator

Vrisiis Kofina, DDS, MS
PRINCIPAL_INVESTIGATOR
Marquette University

Study Locations (Sites)

Marquette University School of Dentistry Graduate Periodontics Clinic
Milwaukee, Wisconsin, 53233
United States

Collaborators and Investigators

Sponsor: Marquette University

  • Vrisiis Kofina, DDS, MS, PRINCIPAL_INVESTIGATOR, Marquette University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-10-19
Study Completion Date2026-12

Study Record Updates

Study Start Date2023-10-19
Study Completion Date2026-12

Terms related to this study

Additional Relevant MeSH Terms

  • Pain, Post Operative
  • Quality of Life