Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial

Description

In this study, the researchers are trying to learn more about the relationship between Polycystic Ovary Syndrome and Obstructive Sleep Apnea (OSA). Obstructive Sleep Apnea is a sleep-related breathing disorder that involves a decrease or complete stop in airflow. The purpose of this study is to find out why some people with obstructive sleep apnea have higher levels of insulin resistance, and the investigators will study the role of hypoxia (low levels of oxygen in the blood at night) in insulin resistance and see if insulin resistance improves during your treatment with CPAP.

Conditions

Polycystic Ovary Syndrome, Obstructive Sleep Apnea

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Study Overview

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Study Details

Study overview

In this study, the researchers are trying to learn more about the relationship between Polycystic Ovary Syndrome and Obstructive Sleep Apnea (OSA). Obstructive Sleep Apnea is a sleep-related breathing disorder that involves a decrease or complete stop in airflow. The purpose of this study is to find out why some people with obstructive sleep apnea have higher levels of insulin resistance, and the investigators will study the role of hypoxia (low levels of oxygen in the blood at night) in insulin resistance and see if insulin resistance improves during your treatment with CPAP.

Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial

Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial

Condition
Polycystic Ovary Syndrome
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94158

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects found to have moderate to severe OSA (AHI \>15)
  • * PCOS diagnosis satisfies both the hyperandrogenic and oligo-ovulatory requirements of Rotterdam criteria
  • * Ages 18-40
  • * BMI 25-45 kg/m2
  • * Fasting insulin \>16
  • * At-risk score on Berlin Questionnaire
  • * Current use of oral contraceptives
  • * Diabetes mellitus (fasting glucose ≥126 mg/dL or 2-h glucose ≥200 mg/dL or HGB A1c ≥6.5%)
  • * Treatment for asthma
  • * Regular tobacco use or alcohol consumption exceeding 1 drink/day
  • * HIV infection or infectious hepatitis
  • * Pregnancy or lactation within the past six months
  • * Prior OSA treatment
  • * Excessive daytime sleepiness as defined as \>16 on the Eppworth Sleepiness Scale or untreated or inadequately treated hypertension (\>150/90)

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Heather Huddleston, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2025-04-30