Urolithin A Supplementation in Middle-aged Adults With Obesity

Description

The goal of this clinical trial is to learn about the effect of urolithin A, a dietary supplement, on blood flow in middle-aged adults with obesity. The main question it aims to answer is: - Does urolithin A supplementation improve blood flow in large and small blood vessels in middle-aged adults with obesity? Participants will be asked to: * Take the dietary supplement daily for 4 weeks * Attend two study visits to have their blood vessels checked, answer questionnaires, and give a sample of blood Researchers will compare people who took the dietary supplement with others who took a placebo to see if the blood flow in the blood vessels improved.

Conditions

Obesity, Vascular Dementia, Cognitive Impairment

Talk to us

Study Overview

On this page

Study Details

Study overview

The goal of this clinical trial is to learn about the effect of urolithin A, a dietary supplement, on blood flow in middle-aged adults with obesity. The main question it aims to answer is: - Does urolithin A supplementation improve blood flow in large and small blood vessels in middle-aged adults with obesity? Participants will be asked to: * Take the dietary supplement daily for 4 weeks * Attend two study visits to have their blood vessels checked, answer questionnaires, and give a sample of blood Researchers will compare people who took the dietary supplement with others who took a placebo to see if the blood flow in the blood vessels improved.

Urolithin A Supplementation to Improve Endothelial and Cerebrovascular Function in Middle-aged Adults With Obesity

Urolithin A Supplementation in Middle-aged Adults With Obesity

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Oklahoma City

Translational GeroScience Laboratory - O'Donoghue Research Building, Oklahoma City, Oklahoma, United States, 73117

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age: 40-64 years old, inclusive
  • * Obesity \[BMI ≥30 kg/m2\]
  • * Ability to read, write, and speak English
  • * Competence to provide written informed consent
  • * Pregnant or breastfeeding women, or women who intend to become pregnant within the study period
  • * History of hypertension
  • * History of type 1 or type 2 diabetes mellitus
  • * Significant cardiac disease or chest pain in the last 6 months
  • * History of depression or anxiety
  • * History of cognitive impairment
  • * History of significant GI disease (e.g., IBS, Crohn's disease)
  • * Allergy or intolerance to one or more of the intervention components
  • * Undergoing treatment for active cancer
  • * History of neurodegenerative disorders (e.g., multiple sclerosis)
  • * Presence of any condition affecting swallowing ability
  • * Any other medical condition that the investigators deem would adversely affect the participant's safety or ability to complete the study

Ages Eligible for Study

40 Years to 64 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Oklahoma,

Andriy Yabluchanskiy, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Oklahoma Health Science Center

Study Record Dates

2025-05