Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering

Description

The aims of this study are to 1) explore the efficacy of hyperbaric oxygen therapy (HBOT) applied at two different pressures compared to sham treatment in relieving signs and symptoms (both physical and psychological) of opioid withdrawal in human subjects associated with methadone dose reductions; and 2): explore whether HBOT can increase the odds of successful methadone dose reduction in patients who are interested in tapering their opioid dose. The investigators aim to explore, through qualitative methods, individual's experiences with treatment for opioid use disorder (OUD).

Conditions

Opioid Use Disorder

Study Overview

Study Details

Study overview

The aims of this study are to 1) explore the efficacy of hyperbaric oxygen therapy (HBOT) applied at two different pressures compared to sham treatment in relieving signs and symptoms (both physical and psychological) of opioid withdrawal in human subjects associated with methadone dose reductions; and 2): explore whether HBOT can increase the odds of successful methadone dose reduction in patients who are interested in tapering their opioid dose. The investigators aim to explore, through qualitative methods, individual's experiences with treatment for opioid use disorder (OUD).

Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering in Human Subjects With Opioid Use Disorder

Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering

Condition
Opioid Use Disorder
Intervention / Treatment

-

Contacts and Locations

Spokane

Spokane Regional Health District, Spokane, Washington, United States, 99201

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Enrollment in a supervised opioid treatment program at the Spokane Regional Health District
  • * Age greater than 18 years
  • * Ability to read, speak, and write English
  • * Ability to provide written informed consent.
  • * Pregnancy
  • * Any other medical or psychiatric condition that the PI, Co-PI (physician of record) or the Spokane Hyperbaric Center medical director determine might compromise safe study participation in the HBOT clinic (including but not limited to active psychosis, history of frequent psychiatric hospitalizations, severe anxiety with claustrophobia, aggression)
  • * Upper respiratory infection
  • * Emphysema
  • * Air cysts in the lung
  • * History of thoracic or ear surgery
  • * Taking the medication Antabuse for alcohol addiction
  • * High fever.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Washington State University,

Layton Matt, MD, PRINCIPAL_INVESTIGATOR, Washington State University

Study Record Dates

2025-12-30