Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * o Patient meets clinical criteria for mild cognitive impairment or early dementia from Alzheimer's disease
- * Patient has evidence of cognitive impairment on neuropsychological testing
- * Patient has not progressed to the moderate stage of dementia based on neuropsychological testing or clinical judgement
- * Amyloid PET imaging and/or CSF analysis consistent with Alzheimer's disease
- * Amyloid PET imaging positive
- * CSF p-Tau/Abeta42 ration \>0.023 and ABeta42 \< 1027\*\*
- * 3T MRI in past 6 months
- * Patient has a care partner
- * Patient under the care of an appropriate BI-Lahey amyloid clinic
- * Patient is on a stable medication regimen
- * o Recent stroke or suspected TIA in the past year
- * Pregnancy
- * Active autoimmune or immunological disease
- * Systemic treatment with immunosuppressants, immunoglobulins, or monoclonal antibodies or their derivatives
- * Bleeding disorder with Plts \< 50,000 or INR \> 1.5
- * On warfarin, heparin, or DOAC
- * On dual antiplatelet therapy
- * Non Alzheimer disease cause of dementia/MCI
- * ApoE e4 homozygote
Ages Eligible for Study
50 Years to 95 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No