RECRUITING

Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

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Conditions

Traumatic Amputation of Lower Extremity

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to investigate the relationship between thigh strength and walking ability and assess if using a blood pressure cuff on the leg improves strength and walking performance.

Official Title

Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

Quick Facts

Study Start:2024-04-01
Study Completion:2027-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05929508

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * At least 18 years old
  2. * History of lower limb unilateral transfemoral amputation.
  3. * At least two years post lower limb amputation
  4. * Able to ambulate independently without the use of aids (i.e., walking cane).
  5. * Able to walk at least 10 minutes continuously without stopping.
  6. * Has a safe residuum with no open wounds on either the residual or intact limb.
  7. * Has a prosthetic limb with materials that are sound and safe to withstand the mobility requirements of the study.
  1. * Younger than 18 years old.
  2. * Inability to give informed consent.
  3. * Neurological disorder that affects gait.
  4. * Participants with significant metal (greater than one orthopaedic screw) in either the residual limb or the sound/intact limb
  5. * Participants who begin taking medications or change dosage of medications that could affect gait, balance, and cardiovascular function during the course of the study.
  6. * Currently pregnant (or intend to become pregnant while participating in study).
  7. * History of any condition where fatiguing contractions or resisted leg contractions are contraindicated.
  8. * Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. open wounds in the leg).
  9. * History of uncontrolled hypertension.
  10. * History of heart failure.
  11. * Head injury within the previous 6 months.
  12. * Seizure disorder.
  13. * History of vascular disease.
  14. * History of thrombosis.
  15. * History of sickle cell trait.
  16. * History of genetic disease

Contacts and Locations

Study Contact

Lindsay Slater
CONTACT
3123558965
slaterlv@uic.edu

Principal Investigator

Lindsay Slater
PRINCIPAL_INVESTIGATOR
University of Illinois at Chicago

Study Locations (Sites)

UIC Physical Therapy Faculty Practice
Chicago, Illinois, 60608
United States

Collaborators and Investigators

Sponsor: University of Illinois at Chicago

  • Lindsay Slater, PRINCIPAL_INVESTIGATOR, University of Illinois at Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-01
Study Completion Date2027-12-31

Study Record Updates

Study Start Date2024-04-01
Study Completion Date2027-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Traumatic Amputation of Lower Extremity