MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants

Eligibility Criteria

• * Age between 18 and 45 years
• * Male or female
• * Right-handed
• * In good general health
• * Women of childbearing capacity: use of effective method of birth control
• * Current or diagnosis within past six months of an DSM-V Axis I or Axis II disorder (self-reported)
• * Current or past six month use of prescription medications indicated for psychiatric conditions (e.g.,depression, anxiety)
• * Current serious medical illness (self-reported)
• * Head injury resulting in loss of consciousness
• * For participants age \> 59 years, a total scaled score \< 8 on the Dementia Rating Scale-2.
• * A clinically-defined neurological disorder including, but not limited to:
• * Any condition likely to be associated with increased intracranial pressure
• * Space occupying brain lesion
• * History of stroke
• * Transient ischemic attack within two years
• * Cerebral aneurysm
• * Dementia
• * Mini Mental Status Exam (MMSE) score of \<24
• * Parkinson's disease
• * Huntington's disease
• * Multiple sclerosis
• * Presence of cochlear implants or other implanted electronic devices or non-removable metal (e.g., non-removable piercing, IUD)
• * History of an eye injury involving metal. Participants who worked with metal may be allowed to participate on a case-by-case basis with prior written approval from BIAC.
• * Claustrophobia or unwillingness to tolerate the confinement associated with being in the MRI scanner.
• * Weight of more than 250 pounds