Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

Description

The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.

Conditions

Parkinson Disease

Study Overview

Study Details

Study overview

The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.

Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

Condition
Parkinson Disease
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
  • * Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
  • * Age at least 18
  • * Able to participate in intraoperative testing
  • * English speaking
  • * Age less than 18
  • * Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Vanderbilt University Medical Center,

Study Record Dates

2025-06-30