ACTIVE_NOT_RECRUITING

Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.

Official Title

Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

Quick Facts

Study Start:2023-07-06
Study Completion:2025-10-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05933681

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
  2. * Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
  3. * Age at least 18
  4. * Able to participate in intraoperative testing
  5. * English speaking
  1. * Age less than 18
  2. * Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)

Contacts and Locations

Principal Investigator

Sarah K Bick, MD
PRINCIPAL_INVESTIGATOR
Vanderbilt University Medical Center

Study Locations (Sites)

Vanderbilt University Medical Center
Nashville, Tennessee, 37232
United States

Collaborators and Investigators

Sponsor: Vanderbilt University Medical Center

  • Sarah K Bick, MD, PRINCIPAL_INVESTIGATOR, Vanderbilt University Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-06
Study Completion Date2025-10-30

Study Record Updates

Study Start Date2023-07-06
Study Completion Date2025-10-30

Terms related to this study

Keywords Provided by Researchers

  • Deep Brain Stimulation
  • Parkinson Disease
  • Cognitive impairment
  • Movement Disorders
  • Brain Diseases

Additional Relevant MeSH Terms

  • Parkinson Disease