RECRUITING

Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.

Official Title

Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise

Quick Facts

Study Start:2025-03-07
Study Completion:2026-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05934708

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 35 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18-35 years of age
  2. * BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths \[15\]
  3. * Not taking contraception or other types of medication that could influence reproductive status
  4. * Regular menstruation
  5. * Non-pregnant
  6. * Medically free from chronic diseases
  7. * Novel to downhill running
  8. * Weight greater than or equal to 110 lbs
  9. * Not taking exogenous hormones
  10. * Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
  1. * Amenorrhea or oligomenorrhea
  2. * Perimenopausal or menopausal
  3. * Recreational or professional trail or downhill runner
  4. * On a form of contraception
  5. * Cardiac disability
  6. * Pacemaker
  7. * Arterial disease
  8. * Uncontrolled hemorrhage
  9. * Blood clots
  10. * Pregnant or trying to become pregnant
  11. * Cancerous lesions
  12. * Sensory or mental impairment
  13. * Unstable fractures
  14. * Weight less than 110 lbs
  15. * Suffering from gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
  16. * Taking exogenous hormones

Contacts and Locations

Study Contact

Todd Schroeder, PhD
CONTACT
3234422180
eschroed@pt.usc.edu

Study Locations (Sites)

Clinical Exercise Research Center
Los Angeles, California, 90033
United States

Collaborators and Investigators

Sponsor: University of Southern California

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-07
Study Completion Date2026-08

Study Record Updates

Study Start Date2025-03-07
Study Completion Date2026-08

Terms related to this study

Keywords Provided by Researchers

  • menstrual cycle
  • exercise

Additional Relevant MeSH Terms

  • Inflammatory Response