SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation

Description

The purpose of SIBYL is to generate clinical validity data for the ability of a future version of Guardant360 developed by Guardant Health to measure response to systemic therapy in patients with unresectable advanced solid tumors. It is necessary to collect clinical data points and treatment outcomes in order to demonstrate clinical validity for longitudinal monitoring with ctDNA and correlation of ctDNA dynamics with therapeutic response, as evaluated by standard methods, including RECIST 1.1 and CT scan measurements.

Conditions

Non-small Cell Lung Cancer, Colorectal Cancer, Breast Cancer

Study Overview

Study Details

Study overview

The purpose of SIBYL is to generate clinical validity data for the ability of a future version of Guardant360 developed by Guardant Health to measure response to systemic therapy in patients with unresectable advanced solid tumors. It is necessary to collect clinical data points and treatment outcomes in order to demonstrate clinical validity for longitudinal monitoring with ctDNA and correlation of ctDNA dynamics with therapeutic response, as evaluated by standard methods, including RECIST 1.1 and CT scan measurements.

SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation

SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation

Condition
Non-small Cell Lung Cancer
Intervention / Treatment

-

Contacts and Locations

Skokie

Orchard Healthcare Research Inc., Skokie, Illinois, United States, 60077-1384

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * History of a prior solid or hematological malignancy within 5 years of enrollment
  • * Life expectancy \< 12 weeks
  • * Unable to collect baseline blood sample prior to starting SOC regimen
  • * Is participating in an interventional clinical trial or another observational study that is evaluating the performance of another genomic test for detecting/predicting clinical response/progression

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Guardant Health, Inc.,

Study Record Dates

2029-08-30