Fitness After Stroke Trial

Description

People living with stroke have very low aerobic fitness, which can negatively impact brain health. Identifying the best exercise which includes exercise stimulus type (interval, continuous) or intensity, how hard to exercise (moderate, high) that benefit aerobic fitness, vascular health, and the brain's main blood vessels after stroke are unknown. This study is designed to determine the preliminary efficacy of high-volume HIIT to moderate intensity exercise using a seated stepper exercise device that allows the arms and legs to move back and forth.

Conditions

Stroke, Stroke, Ischemic, Stroke Hemorrhagic

Study Overview

Study Details

Study overview

People living with stroke have very low aerobic fitness, which can negatively impact brain health. Identifying the best exercise which includes exercise stimulus type (interval, continuous) or intensity, how hard to exercise (moderate, high) that benefit aerobic fitness, vascular health, and the brain's main blood vessels after stroke are unknown. This study is designed to determine the preliminary efficacy of high-volume HIIT to moderate intensity exercise using a seated stepper exercise device that allows the arms and legs to move back and forth.

Investigating Exercise Prescription Parameters on Aerobic Fitness and Vascular Health After Stroke: a Pilot Study

Fitness After Stroke Trial

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Kansas City

University of Kansas Medical Center, Kansas City, Kansas, United States, 66160

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Both sexes between the age of 20-85 years at time of consent
  • * Chronic ischemic or hemorrhagic stroke 6 months to 5 years at consent. People with stroke and newly diagnosed cardiovascular complications had \>50% prevalence of recurrent stroke at 5 years. Index stroke or recurrent stroke on same side as index stroke will be allowed.
  • * Ability to walk over ground with assistive devices and no continuous physical assistance from another person to perform tests for gait speed and six-minute walk test
  • * Exercise continuously for minimum of 30 watts for 3 minutes on the recumbent stepper to demonstrate ability to perform the exercise test.
  • * No aerobic exercise contraindications or other safety/physical concerns during the submaximal exercise test.
  • * Able to communicate with investigators, follow 2-step command \& correctly answer consent comprehension questions
  • * Currently participating in less than 150 minutes of physical activity/week assessed by the Rapid Assessment of Physical Activity
  • * Stable blood pressure \& statin medication doses for 30 days prior to enrollment due to effects on vascular health/hemodynamics
  • * Hospitalization for cardiac or pulmonary disease within past 3 months
  • * Implanted pacemaker or defibrillator limiting exercise performance
  • * Significant ataxia or neglect (score of 2 on NIH stroke scale item 7 or 11)
  • * Reported pain that limits or interferes with activities of daily living and physical activity/exercise
  • * Severe LE spasticity (Ashworth \>2) due to inability to exercise
  • * Recent history (\<3 months) of illicit drug or alcohol abuse or diagnosis of significant mental illness
  • * Major post-stroke depression (Patient Health Questionnaire, PHQ-9 ≥ 1084)
  • * Currently participating in physical therapy targeting lower extremity function or another interventional study that may influence study outcomes
  • * Other significant neurologic, orthopedic or peripheral vascular conditions that would limit exercise participation
  • * Oxygen-dependent chronic obstructive pulmonary disease
  • * Diagnosis of other neurological disease (Multiple Sclerosis, Alzheimer's disease, Parkinson's disease)
  • * Self report pregnancy

Ages Eligible for Study

20 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Kansas Medical Center,

Sandra A Billinger, PhD, PRINCIPAL_INVESTIGATOR, KU Medical Center

Study Record Dates

2025-12