RECRUITING

Persea Americana for Total Health (PATH)-2

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn about the effects of avocado consumption on gastrointestinal health in adults with overweight and obesity. The main questions is aims to answer are: How does avocado consumption affect the gut microbiome? How does avocado consumption affect thinking? Are there connections between the microbiome and cognition? Participants will be asked to eat provided meals with and without avocados for three 4-week periods. At the end of each 4-week period, participants will be asked to provide stool samples and complete computer games that assess thinking and memory.

Official Title

Persea Americana for Total Health (PATH)-2

Quick Facts

Study Start:2023-07-11
Study Completion:2024-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05941728

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:25 Years to 74 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Participants must be between the ages of 25 and 74 years old
  2. * BMI ≥ 25 kg/m2
  3. * Ability to drop off fecal sample within 15 minutes of defecation
  4. * 20/20 or corrected vision
  1. * Avocado allergy or intolerance
  2. * Food allergies or intolerances
  3. * Prior diagnosis of liver or gastrointestinal disease (primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), diabetes, hepatitis, HIV, or cancer
  4. * Women that are pregnant, have given birth in the previous 12 months or are lactating
  5. * Individuals that smoke, use tobacco, abuse drugs, or consume \> 2 alcoholic beverages per day.
  6. * \> 5% weight change in the past month or \> 10% change in the past six months
  7. * Oral antibiotics during the previous 6 weeks.
  8. * Currently taking lipid-lowering medications, oral hypoglycemic agents, or insulin.
  9. * History of malabsorptive or restrictive bariatric surgeries (e.g., gastric bypass, sleeve gastrectomy, adjustable gastric band) or gall bladder removal surgery.
  10. * Are unable to consume the experimental meals/snacks.
  11. * Allergic to latex
  12. * Concurrent enrollment in another dietary, exercise, or medication study

Contacts and Locations

Study Contact

Hannah D Holscher, PhD, RD
CONTACT
217-300-2512
hholsche@illinois.edu
Maggie Oleksiak, MS
CONTACT
maggieo4@illinois.edu

Principal Investigator

Hannah Holscher, PhD, RD
PRINCIPAL_INVESTIGATOR
University of Illinois Urbana Champaign

Study Locations (Sites)

University of Illinois, Urbana Champaign
Urbana, Illinois, 61801
United States

Collaborators and Investigators

Sponsor: University of Illinois at Urbana-Champaign

  • Hannah Holscher, PhD, RD, PRINCIPAL_INVESTIGATOR, University of Illinois Urbana Champaign

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-11
Study Completion Date2024-07

Study Record Updates

Study Start Date2023-07-11
Study Completion Date2024-07

Terms related to this study

Keywords Provided by Researchers

  • Avocado
  • Gastrointestinal microbiome
  • Bile acid profile
  • Inflammation
  • Thinking
  • Glycemia

Additional Relevant MeSH Terms

  • Overweight and Obesity