ACTIVE_NOT_RECRUITING

Spectral Characteristics of Memory Transformation

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.

Official Title

Probing Mechanisms of Procedural Memory Transformation With Cross-frequency Transcranial Alternating Current Stimulation (Cf-tACS) as an Avenue to Sculpt Sensorimotor Behavior

Quick Facts

Study Start:2023-07-01
Study Completion:2026-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05946616

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 years or older (2/3 of the final sample will be ≥60years of age)
  2. * No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head
  3. * Ability to give consent for study participation
  4. * who have access to a personal computer with internet
  1. * • Pregnancy
  2. * Inability to use all ten fingers to type on a standard computer keyboard
  3. * Uncorrected vision, hindering perception of visual cues presented on a standard computer screen
  4. * Medication use at the time of study that may interfere with learning or the effect of tACS, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, dextromethorphan;
  5. * Neuromuscular disorders affecting hand and finger movements necessary for 10-finger keyboard typing
  6. * Presence of neurological or psychiatric disorders
  7. * Presence of scalp injury or disease
  8. * Prior history of seizures
  9. * Prior intracranial surgery
  10. * Prior brain radiotherapy
  11. * Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation
  12. * Metal in head or neck
  13. * Contraindications to MRI (such as severe claustrophobia, implanted medical devices)

Contacts and Locations

Principal Investigator

Kirstin-Friederike Heise, PhD
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Kirstin-Friederike Heise, PhD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-01
Study Completion Date2026-03-31

Study Record Updates

Study Start Date2023-07-01
Study Completion Date2026-03-31

Terms related to this study

Additional Relevant MeSH Terms

  • Healthy