Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

Description

The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.

Conditions

Gestational Diabetes, Oxidative Stress, Vascular Endothelial Function

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.

Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

Condition
Gestational Diabetes
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 years or older
  • * pregnant within 5 years of the study visit
  • * had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes.
  • * or without a history of gestational diabetes
  • * skin diseases
  • * current tobacco or electronic cigarette/vape pen use,
  • * diagnosed or suspected hepatic or metabolic disease including diabetes,
  • * statin or other cholesterol-lowering medication,
  • * current antihypertensive medication,
  • * history of preeclampsia or gestational hypertension,
  • * current pregnancy,
  • * body mass index \<18.5 kg/m2,
  • * allergy to materials used during the experiment.(e.g. latex),
  • * known allergies to study drugs

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Anna Stanhewicz, PhD,

Study Record Dates

2027-06