SMART TRENDS Study

Description

A multicenter, interventional, feasibility comparison with historical controls

Conditions

Moderate to High-risk Noncardiac Surgery

Talk to us

Study Overview

On this page

Study Details

Study overview

A multicenter, interventional, feasibility comparison with historical controls

Acumen HPI Smart Alerts and Smart Trends to Improve Compliance with an Intra-operative Hemodynamic Management Algorithm and Reduce Renal Injury Following Major Elective Noncardiac Surgery.

SMART TRENDS Study

Condition
Moderate to High-risk Noncardiac Surgery
Intervention / Treatment

-

Contacts and Locations

Sacramento

UC Davis Medical Center, Sacramento, California, United States, 95817

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

Detroit

Henry Ford Health System, Detroit, Michigan, United States, 48202

Durham

Duke University, Durham, North Carolina, United States, 27705

Winston-Salem

Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States, 27157

Portland

Oregon Health & Science University, Portland, Oregon, United States, 997239

Greenville

Prisma Health, Greenville, South Carolina, United States, 29615

Seattle

University of Washington, Seattle, Washington, United States, 98195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Signed informed consent
  • * Age ≥ 18 years
  • * ASA Physical Status ≥ 2
  • * Elective noncardiac surgery with expected surgery duration ≥ 3 hours and expected post-operative length of stay of ≥ 3 days
  • * Planned monitoring with an arterial catheter; Cohort 2: without planned arterial catheter insertion
  • * General anesthesia with tracheal intubation and positive pressure ventilation
  • * Inability to comply with the study intra-operative hemodynamic management algorithm such as surgeon request for relative hypotension or fluid restriction or avoidance of vasopressors
  • * Planned vasopressor or inotrope infusion during surgery
  • * Contraindication to intra-arterial blood pressure monitoring
  • * Has previously participated in the SMART TRENDS study
  • * Serum creatine \> 2.0 mg/dL (\> 175 μmol/L) or CKD stage \> 3A
  • * Scheduled for intracranial or cardiac surgery
  • * Patient who is known to be pregnant
  • * Patients on mechanical circulatory support
  • * Emergency surgery
  • * Planned beach-chair positioning
  • * Extreme contraction of the smooth muscle in the arteries and arterioles of the lower arm and hand, such as may be present in patients with Raynaud's disease
  • * Finger or hand deformity that prevents proper placement of finger cuff by visual inspection
  • * Inability to place Acumen IQ finger cuffs due to subject anatomy, condition, or obstructive paraphernalia (such as false nails)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Edwards Lifesciences,

Tina Abdelnour, MS, BSN, STUDY_DIRECTOR, Edwards Lifesciences

Study Record Dates

2026-06