CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

Description

The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.

Conditions

Trauma, Hemorrhage

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Study Overview

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Study Details

Study overview

The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

Condition
Trauma
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 2.Blood/blood component transfusion initiated in prehospital setting or deemed clinically indicated within 60 minutes of arrival at the enrolling trauma center
  • 4. Anticipated admission to intensive care unit (ICU)
  • 1. Wearing NO CAVALIER opt-out bracelet
  • 2. Age \> 90 or \< 18 years of age
  • 3. Isolated fall from standing injury mechanism
  • 4. Known prisoner
  • 5. Known pregnancy
  • 6. Traumatic arrest with \> 5 minutes of CPR without return of vital signs
  • 7. Brain matter exposed or penetrating brain injury
  • 8. Isolated drowning or hanging victims
  • 9. Objection to study voiced by subject or family member at the scene or at the trauma center
  • 10. Inability to obtain IV/IO access
  • 1. Wearing NO CAVALIER opt-out bracelet
  • 2. Age \> 90 or \< 18 years of age
  • 3. Isolated fall from standing injury mechanism
  • 4. Known prisoner
  • 5. Known pregnancy
  • 6. Traumatic arrest with \> 5 minutes of CPR without return of vital signs
  • 7. Brain matter exposed or penetrating brain injury
  • 8. Isolated drowning or hanging victims
  • 9. Objection to study voiced by subject or family member at the scene or at the trauma center
  • 10. Inability to obtain IV access

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Jason Sperry,

Jason Sperry, MD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2028-03