Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection

Description

The purpose of this study is to develop a protocol for biofilms disinfection with a FDA cleared, clinically approved and commercially available Er,Cr:YSGG laser treatments. This protocol will be testing local single topical application of Lasers within the canal system in patients going through routine endodontic treatment, evaluate its potential as anti-biofilm treatment and compare it to other currently used antibacterial protocols.

Conditions

Endodontic Disease, Root Canal Infection

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Study Overview

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Study Details

Study overview

The purpose of this study is to develop a protocol for biofilms disinfection with a FDA cleared, clinically approved and commercially available Er,Cr:YSGG laser treatments. This protocol will be testing local single topical application of Lasers within the canal system in patients going through routine endodontic treatment, evaluate its potential as anti-biofilm treatment and compare it to other currently used antibacterial protocols.

A Clinical Use of Er,Cr:YSGG Laser: an Anti-biofilm Treatment

Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection

Condition
Endodontic Disease
Intervention / Treatment

-

Contacts and Locations

Philadelphia

University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Provision of signed and dated informed consent form.
  • * Stated willingness to comply with all study procedures and availability for the duration of the study.
  • * Male or female (Gender is not an inclusion or exclusion criteria), aged 18 years old or above.
  • * In good general health as evidenced by medical history or non-contributory medical history (Patient can be seen for regular dental appointment in Penn Dental Medicine; American Society of Anesthesiologists (ASA) classes I and II).
  • * Radiographic presence of periapical radiolucency.
  • * Negative response to thermal sensitivity testing (difluorochloromethane at -50 °C, Endo-Ice, Coltène/Whaledent Inc., Cuyahoga Falls, Ohio) or electric pulp testing.
  • * Enough tooth structure for adequate isolation with rubber dam.
  • * No history of previous endodontic treatment on the tooth.
  • * Teeth with single canal, 1 distal canal of lower molar, 1 palatal canal of upper molar.
  • * Patients who report they are pregnant.
  • * Teeth affected by dental trauma.
  • * Periodontal changes (pockets 3 mm, mobility I or gingival edema).
  • * Radiographic presence of resorptive processes.
  • * Per the investigator's discretion, unable or unlikely to comply with study procedure.
  • * Presence of any condition which, in the opinion of the investigator, makes participation in the study not in the individual's best interest.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Pennsylvania,

Bekir Karabucak, DMD, MS., PRINCIPAL_INVESTIGATOR, Chair and Professor of Endodontics. Postdoctoral Endodontics Program, Director.

Flavia Teles, DDS,MS,DMSc, PRINCIPAL_INVESTIGATOR, Associate Professor, Department of Basic & Translational Sciences

Study Record Dates

2027-07