Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Description

In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

Conditions

Nicotine Dependence, Nicotine Vaping

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Study Overview

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Study Details

Study overview

In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Condition
Nicotine Dependence
Intervention / Treatment

-

Contacts and Locations

San Francisco

Zuckerberg San Francisco General Hospital (ZSFG), San Francisco, California, United States, 94110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy on the basis of medical history and limited physical examination.
  • * Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)
  • * • Medications
  • * Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).
  • * Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).
  • * Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).
  • * Any stimulant medications (example: Adderall) generally given for ADHD treatment.
  • * Pregnancy (self-reported and urine pregnancy test)
  • * Breastfeeding (determined by self-report)
  • * Women of childbearing potential must be using an acceptable method of contraception
  • * Inability to read and write in English
  • * A known propylene glycol/vegetable glycerin allergy
  • * Uncomfortable with getting blood drawn

Ages Eligible for Study

21 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, San Francisco,

Neal Benowitz, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2025-09