High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults with HIV

Description

This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognitive impairments (Aim 1) to a greater extent than continuous moderate exercise. Additionally, investigator will seek to identify barriers to engagement in exercise and the participants' perceptions of the study and exercise interventions (Aim 2). This study will enroll 60 participants in Birmingham, Alabama. Data collection will occur at each visit, with baseline data collected at the initial visit with a 3-month follow-up occurring following completion of the intervention.

Conditions

HIV, Arterial Stiffness, Cognitive Dysfunction

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Study Overview

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Study Details

Study overview

This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognitive impairments (Aim 1) to a greater extent than continuous moderate exercise. Additionally, investigator will seek to identify barriers to engagement in exercise and the participants' perceptions of the study and exercise interventions (Aim 2). This study will enroll 60 participants in Birmingham, Alabama. Data collection will occur at each visit, with baseline data collected at the initial visit with a 3-month follow-up occurring following completion of the intervention.

A Pilot Trial of High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Older Adults with HIV

High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults with HIV

Condition
HIV
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 50 years and older
  • * Sedentary lifestyle, defined as \< 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire
  • * Neurocognitive Impairment (as assessed using the BRACE+
  • * Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity
  • * Able to speak, read, and write in English
  • * Willingness to participate in all study procedures
  • * Diagnosis of mitochondrial disease
  • * Active substance abuse or factors preventing compliance or safety
  • * Uncontrolled hypertension, defined as resting BP \> 150/90 mmHG
  • * Chronic kidney disease
  • * Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
  • * Acute myocardial infarction identified by medical history and ECG
  • * Pulmonary disease requiring the use of supplemental oxygen
  • * Poorly controlled diabetes
  • * Neuropsychologically Intact
  • * Orthopedic problems that limit ability to perform exercise
  • * Simultaneous participation in another intervention trial

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Alabama at Birmingham,

Raymond Jones, Ph.D., PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

2028-12