RECRUITING

High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults with HIV

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognitive impairments (Aim 1) to a greater extent than continuous moderate exercise. Additionally, investigator will seek to identify barriers to engagement in exercise and the participants' perceptions of the study and exercise interventions (Aim 2). This study will enroll 60 participants in Birmingham, Alabama. Data collection will occur at each visit, with baseline data collected at the initial visit with a 3-month follow-up occurring following completion of the intervention.

Official Title

A Pilot Trial of High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Older Adults with HIV

Quick Facts

Study Start:2024-02-05
Study Completion:2028-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05965518

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 50 years and older
  2. * Sedentary lifestyle, defined as \< 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire
  3. * Neurocognitive Impairment (as assessed using the BRACE+
  4. * Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity
  5. * Able to speak, read, and write in English
  6. * Willingness to participate in all study procedures
  1. * Diagnosis of mitochondrial disease
  2. * Active substance abuse or factors preventing compliance or safety
  3. * Uncontrolled hypertension, defined as resting BP \> 150/90 mmHG
  4. * Chronic kidney disease
  5. * Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
  6. * Acute myocardial infarction identified by medical history and ECG
  7. * Pulmonary disease requiring the use of supplemental oxygen
  8. * Poorly controlled diabetes
  9. * Neuropsychologically Intact
  10. * Orthopedic problems that limit ability to perform exercise
  11. * Simultaneous participation in another intervention trial

Contacts and Locations

Study Contact

Raymond Jones, Ph.D.
CONTACT
205-996-3569
raymondjones@uabmc.edu

Principal Investigator

Raymond Jones, Ph.D.
PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35205
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

  • Raymond Jones, Ph.D., PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-05
Study Completion Date2028-12

Study Record Updates

Study Start Date2024-02-05
Study Completion Date2028-12

Terms related to this study

Additional Relevant MeSH Terms

  • HIV
  • Arterial Stiffness
  • Cognitive Dysfunction