Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF

Description

The purpose of this study is to demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis

Conditions

Appendicitis

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Study Overview

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Study Details

Study overview

The purpose of this study is to demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR) -A Randomized Controlled Trial

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF

Condition
Appendicitis
Intervention / Treatment

-

Contacts and Locations

San Francisco

Zuckerberg San Francisco General Hospital, San Francisco, California, United States, 94110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 18 years
  • * Planned appendectomy (laparoscopic or open)
  • * Working telephone number or reliable method to contact patient after hospital discharge
  • * Unable to consent
  • * Pregnant Women
  • * Prisoners
  • * Immunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage AIDS
  • * Heart failure
  • * Allergy to bupivacaine
  • * Unlikely to comply with treatment or follow-up
  • * Inpatient consultation for appendicitis
  • * Clinically suspected of sepsis based on Sepsis-3 definition
  • * Current use of antibiotics for other indications
  • * Type 1 Diabetes or uncontrolled hyperglycemia
  • * Surgeon preference
  • * Patient preference
  • * Research team unavailable

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Lucy Kornblith, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2025-06-30