RECRUITING

The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation

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Conditions

Platelet Aggregation, SpontaneousVascular Thrombosisplatelet activationvascular inflammationerythritolaspartamedietary intervention

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design

Official Title

Randomized Controlled Clinical Trial to Gauge the Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation

Quick Facts

Study Start:2023-07-20
Study Completion:2025-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05967741

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * BMI ≥ 27 kg/m2
  1. * • History of blood clot, transient ischemic attack (TIA), stroke, angina, heart attack, or peripheral vascular disease, or current cancer diagnosis.
  2. * Pregnant or lactating women
  3. * Current, prior (within 12 months), or anticipated use of medications for treatment of hyperlipidemia, high blood pressure or diabetes, or any medication that in the opinion of the investigators will confound results.
  4. * Unwilling to forego the use of anti-inflammatory medication during study.
  5. * Unwilling to forego the use of marijuana during the study.
  6. * Use of tobacco.
  7. * Strenuous exerciser (\>4 hours/week at a level more vigorous than walking).
  8. * Surgery or medication for weight loss.
  9. * Diet exclusions: Food allergies or dietary restrictions that may undermine compliance to dietary protocol, routine ingestion of more than 2 sugar-sweetened beverages or 2 alcoholic beverage/day. Unwillingness to consume artificial or noncaloric sweeteners. Habitual consumption (\>10 gram/day) of beverage or foods that contain erythritol. Recent or current weight loss diet.

Contacts and Locations

Study Contact

Kimber L. Stanhope, Ph.D.
CONTACT
5302190914
klstanhope@ucdavis.edu
Marinelle Nunez, B.S.
CONTACT
530-752-2146
mvnunez@ucdavis.edu

Study Locations (Sites)

Ragle Human Nutrition Research Center, University of California, Davis
Davis, California, 95616
United States

Collaborators and Investigators

Sponsor: University of California, Davis

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-20
Study Completion Date2025-06

Study Record Updates

Study Start Date2023-07-20
Study Completion Date2025-06

Terms related to this study

Keywords Provided by Researchers

  • platelet activation
  • vascular inflammation
  • erythritol
  • aspartame
  • dietary intervention

Additional Relevant MeSH Terms

  • Platelet Aggregation, Spontaneous
  • Vascular Thrombosis