The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation

Description

The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design

Conditions

Platelet Aggregation, Spontaneous, Vascular Thrombosis

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Study Overview

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Study Details

Study overview

The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design

Randomized Controlled Clinical Trial to Gauge the Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation

The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation

Condition
Platelet Aggregation, Spontaneous
Intervention / Treatment

-

Contacts and Locations

Davis

Ragle Human Nutrition Research Center, University of California, Davis, Davis, California, United States, 95616

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * BMI ≥ 27 kg/m2
  • * • History of blood clot, transient ischemic attack (TIA), stroke, angina, heart attack, or peripheral vascular disease, or current cancer diagnosis.
  • * Pregnant or lactating women
  • * Current, prior (within 12 months), or anticipated use of medications for treatment of hyperlipidemia, high blood pressure or diabetes, or any medication that in the opinion of the investigators will confound results.
  • * Unwilling to forego the use of anti-inflammatory medication during study.
  • * Unwilling to forego the use of marijuana during the study.
  • * Use of tobacco.
  • * Strenuous exerciser (\>4 hours/week at a level more vigorous than walking).
  • * Surgery or medication for weight loss.
  • * Diet exclusions: Food allergies or dietary restrictions that may undermine compliance to dietary protocol, routine ingestion of more than 2 sugar-sweetened beverages or 2 alcoholic beverage/day. Unwillingness to consume artificial or noncaloric sweeteners. Habitual consumption (\>10 gram/day) of beverage or foods that contain erythritol. Recent or current weight loss diet.

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Davis,

Study Record Dates

2025-06