Effect of Grapes in Inflammatory Bowel Disease

Description

The overall objective of this pilot intervention study is to determine the impact of grape powder (46g/day freeze dried whole grape powder provided by the California Table Grape Commission) on the gut microbiotacomposition in adult patients with the IBD subtype Crohn's disease (CD).

Conditions

Crohn Disease

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Study Overview

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Study Details

Study overview

The overall objective of this pilot intervention study is to determine the impact of grape powder (46g/day freeze dried whole grape powder provided by the California Table Grape Commission) on the gut microbiotacomposition in adult patients with the IBD subtype Crohn's disease (CD).

The Effect of Grapes in Inflammatory Bowel Disease

Effect of Grapes in Inflammatory Bowel Disease

Condition
Crohn Disease
Intervention / Treatment

-

Contacts and Locations

Cleveland

University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States, 44106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Documented diagnosis of Crohns disease. CD outpatients in remission
  • * Harvey Bradshaw-index in remission (\<6 score)
  • * Capable of providing consent to participate.
  • * Able to complete daily surveys and take oral nutrition
  • * Able to record daily meal intake
  • * Short bowel syndrome.
  • * Hospitalized patients.
  • * Individuals who lack consent capacity, including the mentally ill, prisoners, cognitively impaired participants, dementia patients.
  • * Known drug abuse.
  • * Known parasitic disease of the digestive system.
  • * Symptomatic intestinal stricture.
  • * Presence of an ostomy.
  • * Other conditions that would be a contraindication to consumption of the study diets or preclude the participant from completing the study.
  • * Well-founded doubt about the patients cooperation.
  • * Existing pregnancy or lactation.
  • * History of \<1 natural bowel movements per day.
  • * Unable to access to technology that permits the daily completion of study related activities.
  • * Change in IBD medication within past 4 weeks.
  • * Body mass Index \<16 kg/m or ≥35.
  • * Documented C.difficile colitis within four weeks of screening.
  • * Known berry or grape allergy
  • * No probiotic or antibiotic use for the previous 14 days

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Case Western Reserve University,

Abigail Basson, PhD, PRINCIPAL_INVESTIGATOR, Case Western Reserve University

Study Record Dates

2026-02-02