Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines

Eligibility Criteria

• * Adult with a diagnosis of PD by a movement disorders neurologist
• * Previous placement, at least six months, of bilateral Medtronic Precept DBS as standard of care treatment for their PD.
• * Stable and clinically optimized DBS parameters for three months prior to enrollment.
• * Demonstrate the ability to safely mount and dismount a recumbent exercise cycle with an upright back.
• * Willingness to withhold antiparkinsonian medication and DBS stimulation.
• * Exercise clearance using the American College of Sports Medicine (ACSM) Pre-participation Health Screen: a. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provider prior to participation; b. Those who choose not to obtain physician clearance will not be eligible for participation.
• * Diagnosis of dementia or any neurocognitive impairment that compromises the ability to provide informed consent.
• * A musculoskeletal issue that limits one's ability to cycle
• * Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) that impacts motor or cognitive function
• * Uncontrolled cardiovascular risk factor such as a current cardiac arrhythmia, uncontrolled hypertension, untreated deep vein thrombosis, etc.