RECRUITING

Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines

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Conditions

Parkinson DiseaseDeep Brain StimulationDBS

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Twenty-five participants with PD utilizing the Medtronic Percept PC DBS system will be enrolled for this project and complete a single bout of both FE and VE. The 150-minute experimental session will be completed in the OFF antiparkinsonian and Off-DBS state.

Official Title

Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines

Quick Facts

Study Start:2023-08-15
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05972759

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult with a diagnosis of PD by a movement disorders neurologist
  2. * Previous placement, at least six months, of bilateral Medtronic Precept DBS as standard of care treatment for their PD.
  3. * Stable and clinically optimized DBS parameters for three months prior to enrollment.
  4. * Demonstrate the ability to safely mount and dismount a recumbent exercise cycle with an upright back.
  5. * Willingness to withhold antiparkinsonian medication and DBS stimulation.
  6. * Exercise clearance using the American College of Sports Medicine (ACSM) Pre-participation Health Screen: a. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provider prior to participation; b. Those who choose not to obtain physician clearance will not be eligible for participation.
  1. * Diagnosis of dementia or any neurocognitive impairment that compromises the ability to provide informed consent.
  2. * A musculoskeletal issue that limits one's ability to cycle
  3. * Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) that impacts motor or cognitive function
  4. * Uncontrolled cardiovascular risk factor such as a current cardiac arrhythmia, uncontrolled hypertension, untreated deep vein thrombosis, etc.

Contacts and Locations

Study Contact

MacKenzie Dunlap, BS
CONTACT
216-219-3949
dunlapm4@ccf.org
Elizabeth Jansen, MPH
CONTACT
216-445-3866
aej26@case.edu

Study Locations (Sites)

Cleveland Clinic
Cleveland, Ohio, 44195
United States
Cleveland Clinic
Cleveland, Ohio, 44195
United States

Collaborators and Investigators

Sponsor: The Cleveland Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-08-15
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2023-08-15
Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

  • Deep Brain Stimulation
  • DBS

Additional Relevant MeSH Terms

  • Parkinson Disease