Effect of Mediterranean Diet in Inflammatory Bowel Disease

Description

The effects of diet on inflammatory bowel disease is an under-studied area of research. The investigators are interested in further investigating the role that diet contributes to inflammatory bowel disease severity. The investigators will collect blood and stool samples from patients with inflammatory bowel disease (IBD) before and after diet changes. The stool samples will be analyzed using metabolomics and microbiome analysis to determine changes after the new diet has been implemented. The investigators will then compare changes in the patient's overall disease state by measuring markers of inflammation including C-reactive protein (CRP) and fecal calprotectin to determine how this diet affects the disease state.

Conditions

Inflammatory Bowel Disease

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Study Overview

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Study Details

Study overview

The effects of diet on inflammatory bowel disease is an under-studied area of research. The investigators are interested in further investigating the role that diet contributes to inflammatory bowel disease severity. The investigators will collect blood and stool samples from patients with inflammatory bowel disease (IBD) before and after diet changes. The stool samples will be analyzed using metabolomics and microbiome analysis to determine changes after the new diet has been implemented. The investigators will then compare changes in the patient's overall disease state by measuring markers of inflammation including C-reactive protein (CRP) and fecal calprotectin to determine how this diet affects the disease state.

Implementing Metabolomics Informed Diet on Inflammatory Bowel Disease Patients

Effect of Mediterranean Diet in Inflammatory Bowel Disease

Condition
Inflammatory Bowel Disease
Intervention / Treatment

-

Contacts and Locations

San Diego

University of California, San Diego, San Diego, California, United States, 92161

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 years old or older
  • * Meet classification criteria for inflammatory bowel disease including those with mild to moderate Crohn's Disease as defined by a Crohn's disease activity index between 150-450, with fecal calprotectin\>250, within 1 month of enrollment.
  • * Unable to provide informed consent
  • * History of or current drug abuse
  • * Pregnancy
  • * Start or change in dose of standard-of-care treatment within 12 weeks of the screening
  • * Known allergy to any component of the proposed diet
  • * Subjects with significant other medical or psychiatric comorbidities and /or medication use which in
  • * physician's clinical judgment might difficult the interpretation of the results
  • * Patients that are not on a stable dose of medications, for instance, steroids, in between samples collection
  • * Patients on antibiotics
  • * Patients with C difficile infection within 4 weeks of enrollment

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Study Record Dates

2028-08-01