Role of Acetaldehyde in the Development of Oral Cancer

Description

This is a minimal risk intervention study where healthy volunteers and individuals with Fanconi anemia will consume a single dose of alcohol and provide primarily non-invasive biological samples at various time points. Biospecimens to be collected include saliva, oral cells collected via mouthwash and cheek brush, and urine. The collection of two blood samples (5 mL each) will be optional and banked for future use.

Conditions

Alcohol-Related Carcinoma, Fanconi Anemia, Oral Cavity Carcinoma

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Study Overview

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Study Details

Study overview

This is a minimal risk intervention study where healthy volunteers and individuals with Fanconi anemia will consume a single dose of alcohol and provide primarily non-invasive biological samples at various time points. Biospecimens to be collected include saliva, oral cells collected via mouthwash and cheek brush, and urine. The collection of two blood samples (5 mL each) will be optional and banked for future use.

Dissecting the Role of Acetaldehyde in Oral Carcinogenesis

Role of Acetaldehyde in the Development of Oral Cancer

Condition
Alcohol-Related Carcinoma
Intervention / Treatment

-

Contacts and Locations

Minneapolis

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States, 55455

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 21-45 years of age for alcohol drinkers
  • * Occasionally consume alcohol
  • * At least 1 drink per month for healthy volunteers
  • * At least 1 drink in the last 3 months for Fanconi anemia patients
  • * Meets one of the three criteria
  • * Healthy volunteer - ALDH2\*1/1\* homozygotes-not of Eastern Asian decent;
  • * Healthy volunteer - ALDH2\*1/2\* heterozygotes-of Eastern Asian decent and experience flushing when drinking
  • * Individual's with Fanconi anemia (FA).
  • * 18-45 years of age for non-drinkers
  • * Never consume alcohol/not had alcohol in the last 6 months
  • * Healthy volunteers.
  • * Non-smoker (smoked \< 100 cigarettes in a lifetime)
  • * Pregnant or nursing
  • * Taking any medication or drug that might affect alcohol use and absorption or that might be affected by alcohol consumption
  • * Healthy volunteers who have taken any antibiotics in the last 3 months
  • * Currently consuming more than 21 drinks per week
  • * Have any history of alcohol or drug related problems
  • * Current or former tobacco/nicotine product(s) user
  • * Any regular use of tobacco/nicotine products or marijuana in the last year (cigarettes, e-cigarettes, cigars, pipes, smokeless tobacco)
  • * "Trying" or limited use of any nicotine products or marijuana in the last 1 month
  • * Active infection (influenza, cold, COVID, respiratory / sinus infection) - admission in the study will be delayed pending improved health
  • * Non-FA volunteers who have an unstable medical condition or condition that could be affected by alcohol consumption (insulin-dependent diabetes, ulcers, heart issues)
  • * Experience severe adverse events (nausea, blacking out) when consuming even low doses of alcohol

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Masonic Cancer Center, University of Minnesota,

Study Record Dates

2027-09-30