REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)

Description

The purpose of this study is to evaluate the safety and efficacy of zipalertinib in combination with standard first-line platinum-based chemotherapy compared to chemotherapy alone, in patients with locally advanced or metastatic NSCLC with EGFR ex20ins mutations.

Conditions

Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation

Study Overview

Study Details

Study overview

The purpose of this study is to evaluate the safety and efficacy of zipalertinib in combination with standard first-line platinum-based chemotherapy compared to chemotherapy alone, in patients with locally advanced or metastatic NSCLC with EGFR ex20ins mutations.

Randomized, Controlled, Open-label, Phase 3, Global Multi - Center Trial to Assess the Efficacy and Safety of Zipalertinib Plus Chemotherapy Versus Chemotherapy Alone, in Patients With Previously Untreated, Locally Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations

REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)

Condition
Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation
Intervention / Treatment

-

Contacts and Locations

Henderson

Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada, United States, 89052

Henderson

Comprehensive Cancer Centers of Nevada - Horizon Ridge Henderson, Henderson, Nevada, United States, 89052

Henderson

Comprehensive Cancer Centers of Nevada - Southeast Henderson - Stephanie, Henderson, Nevada, United States, 89074

Las Vegas

Comprehensive Cancer Centers of Nevada - Summerlin Medical Center II, Las Vegas, Nevada, United States, 89144

Las Vegas

Comprehensive Cancer Centers of Nevada - Southwest, Las Vegas, Nevada, United States, 89148

Las Vegas

Comprehensive Cancer Centers of Nevada - Central Valley - Twain, Las Vegas, Nevada, United States, 89169

Las Vegas

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada, United States, 89218

Canton

Gabrail Cancer and Research Center, Canton, Ohio, United States, 44718

Toledo

The Toledo Clinic Cancer Center, Toledo, Ohio, United States, 43623

Houston

University of Texas MD Anderson Cancer Center, Houston, Texas, United States, 77030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Taiho Oncology, Inc.,

    Study Record Dates

    2026-08-24