Evaluating Treatments for Suicidal Veterans With PTSD

Description

Posttraumatic Stress Disorder (PTSD) is a significant driver of suicide risk among Veterans, but there is a critical knowledge gap about how to treat PTSD among people at elevated risk for suicide. Although evidence-based treatments for PTSD reduce suicide risk, Veterans at high risk for suicidal behavior rarely receive these potentially life-saving treatments. Prior research suggests that a treatment that combines Dialectical Behavior Therapy (DBT) with the DBT Prolonged Exposure protocol (DBT PE) for PTSD improves both PTSD and suicide-related outcomes. This study will evaluate whether DBT + DBT PE improves these outcomes more than Prolonged Exposure plus suicide risk management, the gold standard VA care for this population. The proposed study will also examine factors that make it easier and harder to implement these treatments in VA settings. The results will help to inform treatment guidelines for this high-priority Veteran population.

Conditions

Self-directed Violence, Post-traumatic Stress Disorder (PTSD)

Study Overview

Study Details

Study overview

Posttraumatic Stress Disorder (PTSD) is a significant driver of suicide risk among Veterans, but there is a critical knowledge gap about how to treat PTSD among people at elevated risk for suicide. Although evidence-based treatments for PTSD reduce suicide risk, Veterans at high risk for suicidal behavior rarely receive these potentially life-saving treatments. Prior research suggests that a treatment that combines Dialectical Behavior Therapy (DBT) with the DBT Prolonged Exposure protocol (DBT PE) for PTSD improves both PTSD and suicide-related outcomes. This study will evaluate whether DBT + DBT PE improves these outcomes more than Prolonged Exposure plus suicide risk management, the gold standard VA care for this population. The proposed study will also examine factors that make it easier and harder to implement these treatments in VA settings. The results will help to inform treatment guidelines for this high-priority Veteran population.

A Hybrid Effectiveness-Implementation Trial of Treatments for Veterans With PTSD at Elevated Acute Risk for Suicide

Evaluating Treatments for Suicidal Veterans With PTSD

Condition
Self-directed Violence
Intervention / Treatment

-

Contacts and Locations

Minneapolis

Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota, United States, 55417-2309

Durham

Durham VA Medical Center, Durham, NC, Durham, North Carolina, United States, 27705-3875

Seattle

VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle, Washington, United States, 98108-1532

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * PTSD
  • * Recent and repeated self-directed violence
  • * Current suicidal ideation
  • * Emotion dysregulation
  • * Veteran eligible for VHA mental health care at participating site (Seattle, Minneapolis, and Durham VAs)
  • * Age 18+
  • * Willing to participate in all study activities
  • * Unable to maintain safety independently
  • * Currently engaged in and/or recent (past year) history of receiving a sufficient dose of DBT or PE
  • * Plan to move away or be unavailable for \>4 weeks in the next 18 months
  • * Unable to sufficiently comprehend study procedures due to lack of English proficiency or moderate to severe cognitive impairment

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Melanie S Harned, PhD, PRINCIPAL_INVESTIGATOR, VA Puget Sound Health Care System Seattle Division, Seattle, WA

Study Record Dates

2027-07-30