RECRUITING

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when vancomycin should and should not be used * Unit-level feedback on overall vancomycin use within and across centers * Clinician education.

Official Title

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)

Quick Facts

Study Start:2023-08-21
Study Completion:2026-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05975671

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Admitted to one of the participating PICUs during the study period
  1. * None

Contacts and Locations

Study Contact

Kathleen Chiotos, MD, MSCE
CONTACT
215-590-5505
chiotosk@chop.edu
Kai Inoki, MPH
CONTACT
215-590-5505
meyahnwid@chop.edu

Principal Investigator

Kathleen Chiotos, MD, MSCE
PRINCIPAL_INVESTIGATOR
children's hospital of philadelphia

Study Locations (Sites)

Children's Healthcare of Atlanta
Atlanta, Georgia, 30322
United States
Johns Hopkins Children's Center
Baltimore, Maryland, 21287
United States
St. Louis Children's Hospital
Saint Louis, Missouri, 63110
United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19146
United States

Collaborators and Investigators

Sponsor: Children's Hospital of Philadelphia

  • Kathleen Chiotos, MD, MSCE, PRINCIPAL_INVESTIGATOR, children's hospital of philadelphia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-08-21
Study Completion Date2026-01

Study Record Updates

Study Start Date2023-08-21
Study Completion Date2026-01

Terms related to this study

Keywords Provided by Researchers

  • Sepsis
  • Vancomycin use
  • methicillin-resistant Staphylococcus aureus (MRSA)
  • Antibiotic Stewardship
  • Implementation science

Additional Relevant MeSH Terms

  • Sepsis
  • Sepsis Mrsa
  • Sepsis Bacteremia
  • Antimicrobial - Induced Nephropathy
  • Sepsis, Severe
  • Septic Shock
  • Septic Syndrome