Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study

Description

Through the proposed Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement (SCOPE) study, the investigators will design and evaluate an overdose prevention and HIV prevention study among people who use drugs (PWUD). Specifically, SCOPE will provide access to drug-checking services for PWUD to better understand the contents of the drug supply, in combination with PrEP for those who are HIV-, to both reduce overdose and HIV among PWUD in Baltimore City.

Conditions

HIV Infections

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Study Overview

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Study Details

Study overview

Through the proposed Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement (SCOPE) study, the investigators will design and evaluate an overdose prevention and HIV prevention study among people who use drugs (PWUD). Specifically, SCOPE will provide access to drug-checking services for PWUD to better understand the contents of the drug supply, in combination with PrEP for those who are HIV-, to both reduce overdose and HIV among PWUD in Baltimore City.

Impact of a Novel HIV Peer Navigation and Overdose Prevention Intervention on Engagement in the HIV Prevention and Treatment Cascade

Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study

Condition
HIV Infections
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins School of Public Health, Baltimore, Maryland, United States, 21205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 years or older,
  • * self-reports having used illicit stimulants or opioids at least once in the past 3 months,
  • * self-reports being HIV negative
  • * reports injection drug use in the past 6 months OR reports at least one of the following indicators of sexual HIV risk exposure in the past 6 months:
  • 1. Sexually Transmitted Infection (STI) diagnosis in the past 6 months
  • 2. "Condom-less" vaginal or anal sex in the past 6 months
  • * Willing to provide a urine sample for urine drug screening of substances
  • * Willing to undergo rapid HIV testing
  • * Willing to undergo STI testing
  • * Determined to be too high or drunk or cognitively impaired, less than 18 years of age
  • * unwilling to provide all required biological specimens (Phase 3 only)
  • * unwilling/unable to give consent

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins Bloomberg School of Public Health,

Susan Sherman, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins Bloomberg School of Public Health

Study Record Dates

2026-06-30