RECRUITING

Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this randomized controlled trial is to examine if there is a relationship between the addition of the genicular nerve block and anterior femoral cutaneous nerve block in providing analgesia and the use of oral and intravenous medication in patients undergoing a total knee arthroplasty. The main questions it aims to answer are: 1. Does incorporating genicular nerve block and anterior femoral cutaneous nerve block to our current standard of care reduce patients' total opioid consumption in the first 24 hours after total knee arthroplasty (TKA) surgery? 2. Does incorporating genicular nerve block and anterior femoral cutaneous nerve block to our current standard of care reduce patients' worst numeric rating scale (NRS) pain score in the post-anesthesia care unit (PACU)? 3. Does incorporating genicular nerve block and anterior femoral cutaneous nerve block to our current standard of care result in earlier discharge from the post-anesthesia care unit (PACU)? 4. Does incorporating genicular nerve block and anterior femoral cutaneous nerve block to our current standard of care reduce patients' total opioid consumption in the first 7 days after total knee arthroplasty (TKA) surgery? 5. Does incorporating genicular nerve block and anterior femoral cutaneous nerve block to our current standard of care reduce patients' numerical rating scale (NRS) pain (both at rest and during movement) in the first 24 and 48 hours after surgery? Participants will be randomly assigned to receive the genicular nerve block and anterior femoral cutaneous nerve block in addition to standard of care (intervention group), or not receive the nerve blocks (control group). Comparing the intervention group to the control group, the researcher's primary outcomes are numerical pain in the post-anesthesia care unit and cumulative opioid consumption during the first 24 hours.

Official Title

A Randomized Controlled Trial of Ultrasound Guided Knee Genicular Nerve Block and Anterior Femoral Cutaneous Nerve Block for Primary Total Knee Arthroplasty

Quick Facts

Study Start:2023-06-07
Study Completion:2026-05-22
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05980546

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * patients age 18-80
  2. * patients undergoing ambulatory unilateral total knee arthroplasty, including 23 hour stay cohort
  3. * ASA I-III
  4. * BMI \< 35
  1. * history of chronic pain syndromes
  2. * chronic opioid use (daily morphine milligram equivalents \> 30 mg for at least 3 months)
  3. * contraindication to peripheral nerve blocks
  4. * contraindication to neuraxial anesthesia
  5. * history of peripheral neuropathy or pre-existing neurological deficits
  6. * Psychiatrics or cognitive disorder that prohibit patient from following study protocol
  7. * allergy to local anesthetic or study medications
  8. * multiligament surgery
  9. * history of substance abuse
  10. * infection at the site of injection
  11. * chronic kidney disease
  12. * currently taking anticonvulsants

Contacts and Locations

Study Contact

Angela Puglisi
CONTACT
646-714-6849
puglisia@hss.edu
Justas Lauzadis, PhD
CONTACT
212-774-2946
lauzadisj@hss.edu

Principal Investigator

Jiabin Liu, MD/PhD
PRINCIPAL_INVESTIGATOR
Hospital for Special Surgery, New York

Study Locations (Sites)

Hospital for Special Surgery
New York, New York, 10021
United States

Collaborators and Investigators

Sponsor: Hospital for Special Surgery, New York

  • Jiabin Liu, MD/PhD, PRINCIPAL_INVESTIGATOR, Hospital for Special Surgery, New York

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-06-07
Study Completion Date2026-05-22

Study Record Updates

Study Start Date2023-06-07
Study Completion Date2026-05-22

Terms related to this study

Additional Relevant MeSH Terms

  • Total Knee Replacement
  • Genicular Nerve Block
  • Opioid Use