Assessment of Methadone Dose Taken

Description

Proof of concept: Pilot Study A Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone levels in interstitial fluid (ISF). An RMM could be used as a medication adherence monitor and would allow for the physician, counselor, patient, or family member to remotely verify that a physician-prescribed dose has been taken.

Conditions

Methadone Toxicity, Methadone Overdose, Pain, Chronic, Drug Metabolism, Poor, CYP2D6-Related, Metabolism Medication Toxicity

Study Overview

Study Details

Study overview

Proof of concept: Pilot Study A Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone levels in interstitial fluid (ISF). An RMM could be used as a medication adherence monitor and would allow for the physician, counselor, patient, or family member to remotely verify that a physician-prescribed dose has been taken.

Assessment of Methadone Dose Taken

Assessment of Methadone Dose Taken

Condition
Methadone Toxicity
Intervention / Treatment

-

Contacts and Locations

Lemon Grove

Synergy, Lemon Grove, California, United States, 91945

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-70
  • * A prescription for methadone for chronic pain at a dose of 10mg or more for at least one week.
  • * Taking methadone as prescribed during the last 4 days before consent to participate in the study.
  • * Age \<18 or \>70
  • * A condition preventing or complicating ISF collection
  • * dermatological (skin) condition
  • * immunodeficiency
  • * recent blood donation
  • * anemia
  • * end stage renal disease
  • * liver cirrhosis
  • * cancer
  • * congestive heart failure
  • * bleeding diathesis
  • * tuberculosis (TB)
  • * Any active severe depression
  • * suicidal ideation
  • * mania symptoms
  • * Pregnancy
  • * Intending to become pregnant during the course of the study
  • * Enrolled in a substance use disorder treatment program
  • * Under a conservatorship.

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Cari Health Inc.,

Charmaine Semenluk, MD, PRINCIPAL_INVESTIGATOR, Synergy Research Inc.

Study Record Dates

2026-04