Prevention of Anhedonia in Children

Description

This trial will test the effects of a positive emotion-focused preventive intervention on reward responsiveness in children of mothers with histories of depression and anhedonia.

Conditions

Anhedonia, Depression

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Study Overview

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Study Details

Study overview

This trial will test the effects of a positive emotion-focused preventive intervention on reward responsiveness in children of mothers with histories of depression and anhedonia.

Reward Responsiveness As a Prevention Target in Youth At Risk for Anhedonia

Prevention of Anhedonia in Children

Condition
Anhedonia
Intervention / Treatment

-

Contacts and Locations

Nashville

Jesup/Hobbs Building, Nashville, Tennessee, United States, 37203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Biological mothers with past or current MDD with anhedonia and their 8- to 12-year-old children
  • * Child and biological mother can read and speak fluently in English
  • * Child and mother have access to a computer or tablet and internet for videoconferencing
  • * For compensation purposes, child and biological mothers must be U.S. citizens
  • * Children with past or current major depressive disorder (MDD) and/or anhedonia lasting most of the day, nearly every day for at least 2 weeks based on semi-structured interviews will be excluded
  • * Mothers or children with intellectual or developmental disabilities
  • * Mothers with past 6 months substance use disorder with moderate or greater severity
  • * Children or mothers with a lifetime history of a manic or hypomanic episode/bipolar disorder
  • * Children or mothers with a psychotic disorder (e.g., schizophrenia)
  • * Children or mothers with visual or hearing impairments that interfere with completing study measures and sessions
  • * Child offspring of a mother who has previously participated in the study with another biological child
  • * Children taking medications for emotional or behavioral problems other than SSRIs (stable dose for 6 weeks before time of enrollment) or psychostimulants

Ages Eligible for Study

8 Years to 12 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Vanderbilt University,

Study Record Dates

2025-07