ACTIVE_NOT_RECRUITING

Prevention of Anhedonia in Children

Conditions

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This trial will test the effects of a positive emotion-focused preventive intervention on reward responsiveness in children of mothers with histories of depression and anhedonia.

Official Title

Reward Responsiveness as a Prevention Target in Youth At Risk for Anhedonia

Quick Facts

Study Start:2023-11-10

Study Completion:2026-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05988138

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:8 Years to 12 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:CHILD

Inclusion Criteria	Exclusion Criteria
* Biological mothers with past or current MDD with anhedonia and their 8- to 12-year-old children * Child and biological mother can read and speak fluently in English * Child and mother have access to a computer or tablet and internet for videoconferencing * For compensation purposes, child and biological mothers must be U.S. citizens	* Children with past or current major depressive disorder (MDD) and/or anhedonia lasting most of the day, nearly every day for at least 2 weeks based on semi-structured interviews will be excluded * Mothers or children with intellectual or developmental disabilities * Mothers with past 6 months substance use disorder with moderate or greater severity * Children or mothers with a lifetime history of a manic or hypomanic episode/bipolar disorder * Children or mothers with a psychotic disorder (e.g., schizophrenia) * Children or mothers with visual or hearing impairments that interfere with completing study measures and sessions * Child offspring of a mother who has previously participated in the study with another biological child * Children taking medications for emotional or behavioral problems other than SSRIs (stable dose for 6 weeks before time of enrollment) or psychostimulants

Inclusion Criteria

Exclusion Criteria

* Biological mothers with past or current MDD with anhedonia and their 8- to 12-year-old children
* Child and biological mother can read and speak fluently in English
* Child and mother have access to a computer or tablet and internet for videoconferencing
* For compensation purposes, child and biological mothers must be U.S. citizens

* Children with past or current major depressive disorder (MDD) and/or anhedonia lasting most of the day, nearly every day for at least 2 weeks based on semi-structured interviews will be excluded
* Mothers or children with intellectual or developmental disabilities
* Mothers with past 6 months substance use disorder with moderate or greater severity
* Children or mothers with a lifetime history of a manic or hypomanic episode/bipolar disorder
* Children or mothers with a psychotic disorder (e.g., schizophrenia)
* Children or mothers with visual or hearing impairments that interfere with completing study measures and sessions
* Child offspring of a mother who has previously participated in the study with another biological child
* Children taking medications for emotional or behavioral problems other than SSRIs (stable dose for 6 weeks before time of enrollment) or psychostimulants

Contacts and Locations

Study Locations (Sites)

Jesup/Hobbs Building

Nashville, Tennessee, 37203

United States

Collaborators and Investigators

Sponsor: Vanderbilt University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-11-10

Study Completion Date2026-01

Study Record Updates

Study Start Date2023-11-10

Study Completion Date2026-01

Terms related to this study

Additional Relevant MeSH Terms

Anhedonia
Depression