RECRUITING

Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine whether transcutaneous electrical acustimulation (TEA) alters systemic sclerosis (SSc)-related colonic and anorectal physiology by enhancing autonomic nervous system (ANS) function. The study will examine the effects of TEA on slow colonic transit (SCT) and rectal hyposensitivity (RH), to examine whether TEA improves autonomic dysfunction and modulates inflammatory pathways.

Official Title

Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis

Quick Facts

Study Start:2024-02-17
Study Completion:2029-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05989763

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Zsuzsanna H McMahan, MD, MHS (M-PI)
CONTACT
7135007531
Zsuzsanna.H.McMahan@uth.tmc.edu
Sharvari R Kamat
CONTACT
713-500-6898
Sharvari.R.Kamat@uth.tmc.edu

Principal Investigator

Zsuzsanna H McMahan, MD, MHS (M-PI)
PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston

Study Locations (Sites)

The University of Texas Health Science Center at Houston
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center, Houston

  • Zsuzsanna H McMahan, MD, MHS (M-PI), PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center, Houston

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-17
Study Completion Date2029-09-01

Study Record Updates

Study Start Date2024-02-17
Study Completion Date2029-09-01

Terms related to this study

Additional Relevant MeSH Terms

  • Systemic Sclerosis
  • Constipation
  • Gastrointestinal Motility Disorder
  • Autonomic Dysfunction