RECRUITING

A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients

Conditions

Cognitive Impairment Cognitive Decline Cognitive Aging Brain Stimulation functional MRI Computational Modeling Finite Element Method (FEM)

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy control

Official Title

A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients

Quick Facts

Study Start:2024-04-24

Study Completion:2025-06-05

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05998031

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years to 95 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age 60-95 years * Montreal Cognitive Assessment (MoCA) score 18 and above (scores will be adjusted for education) * Able to receive electrical stimulation * Ability to comprehend conversational voices * Adequate motor capacity to operate computer mouse and click-button in-scanner * Ability to participate in the intervention and attend training sessions	* Failure to provide informed consent * Contraindications to MRI recording (e.g., any kind of ferrous metallic stents or ferrous metal objects in the body, heart valve prosthesis, or other metal implants, claustrophobia, neurostimulation system, defibrillator, pacemaker, or other implanted device) * Left-handed, or left hand dominant * History of neurological, seizures, and psychiatric disorders, traumatic brain injury, incidence of stroke involving large vessel * Terminal illness with life expectancy less than 12 months, as determined by physician * Brain tumor or any foreign body known or previously identified in brain * Cancer in active treatment, besides skin cancer * Currently on GABAergic or glutamatergic medications, or on calcium or sodium channel blockers, which alter or block the ability of tDCS to facilitate tissue excitability * Unable to communicate because of severe hearing loss or speech disorder * Severe sensory impairment * Inability to communicate in English * Severe visual impairment, which would preclude completion of the assessment and/or intervention * No physical impairment precluding motor response or lying still for an hour in the scanner that could confound study findings

Inclusion Criteria

Exclusion Criteria

* Age 60-95 years
* Montreal Cognitive Assessment (MoCA) score 18 and above (scores will be adjusted for education)
* Able to receive electrical stimulation
* Ability to comprehend conversational voices
* Adequate motor capacity to operate computer mouse and click-button in-scanner
* Ability to participate in the intervention and attend training sessions

* Failure to provide informed consent
* Contraindications to MRI recording (e.g., any kind of ferrous metallic stents or ferrous metal objects in the body, heart valve prosthesis, or other metal implants, claustrophobia, neurostimulation system, defibrillator, pacemaker, or other implanted device)
* Left-handed, or left hand dominant
* History of neurological, seizures, and psychiatric disorders, traumatic brain injury, incidence of stroke involving large vessel
* Terminal illness with life expectancy less than 12 months, as determined by physician
* Brain tumor or any foreign body known or previously identified in brain
* Cancer in active treatment, besides skin cancer
* Currently on GABAergic or glutamatergic medications, or on calcium or sodium channel blockers, which alter or block the ability of tDCS to facilitate tissue excitability
* Unable to communicate because of severe hearing loss or speech disorder
* Severe sensory impairment
* Inability to communicate in English
* Severe visual impairment, which would preclude completion of the assessment and/or intervention
* No physical impairment precluding motor response or lying still for an hour in the scanner that could confound study findings

Contacts and Locations

Study Contact

Aprinda I Queen, PhD

CONTACT

3522948990

aiqueenlab@phhp.ufl.edu

Principal Investigator

Aprinda I Queen, PhD

PRINCIPAL_INVESTIGATOR

University of Florida

Study Locations (Sites)

University of Florida

Gainesville, Florida, 32610

United States

Collaborators and Investigators

Sponsor: University of Florida

Aprinda I Queen, PhD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-24

Study Completion Date2025-06-05

Study Record Updates

Study Start Date2024-04-24

Study Completion Date2025-06-05

Terms related to this study

Keywords Provided by Researchers

Cognitive Aging
Brain Stimulation
functional MRI
Computational Modeling
Finite Element Method (FEM)

Additional Relevant MeSH Terms

Cognitive Impairment
Cognitive Decline