RECRUITING

Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated with Radioactive Iodine for Thyroid Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The association of radioiodine therapy for the treatment of thyroid cancer with nasolacrimal duct obstruction has been well documented in the medical literature. Prior case reports have documented radioactive iodine detection in the tears of patients following radioiodine therapy. It is possible that radioactive uptake by the cells in the lacrimal sac and nasolacrimal duct lead to inflammation, fibrosis, and obstruction of the tear duct over time. A recent study has shown that the administration of artificial tears decreases the level of detectable radioiodine in the tears of patients undergoing radioiodine therapy for thyroid cancer. The purpose of this study will be to assess whether administering tears after radioactive iodine therapy for thyroid cancer decreases the incidence of nasolacrimal duct obstruction in the two years following radioactive iodine treatment.

Official Title

The Use of Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Who Are Treated with Radioactive Iodine for Thyroid Cancer

Quick Facts

Study Start:2023-08-21
Study Completion:2027-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05999630

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Radio-iodine therapy for thyroid cancer
  2. 2. Radioiodine therapy ≥150 mCi
  3. 3. Age 18 or older
  1. 1. Use of eye drops, other than artificial tears
  2. 2. History of periocular trauma with tear duct involvement/lacrimal gland trauma
  3. 3. History of lacrimal drainage disease: canaliculitis, dacryocystitis
  4. 4. Prior radiotherapy
  5. 5. Current or prior use of chemotherapy drugs (i.e. 5-fluorouracil, docetaxel)
  6. 6. Medical conditions that predispose to NLD stenosis (i.e. sarcoidosis, granulomatosis with polyangiitis, chronic lymphocytic leukemia)
  7. 7. Nasolacrimal duct obstruction at baseline

Contacts and Locations

Study Contact

Marybeth Carter
CONTACT
615-936-1639
marybeth.l.carter@vumc.org

Study Locations (Sites)

Vanderbilt University Medical Center
Nashville, Tennessee, 37232
United States

Collaborators and Investigators

Sponsor: Vanderbilt University Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-08-21
Study Completion Date2027-12-31

Study Record Updates

Study Start Date2023-08-21
Study Completion Date2027-12-31

Terms related to this study

Keywords Provided by Researchers

  • Nasolacrimal Duct Obstruction
  • Artificial Tears
  • Thyroid Cancer

Additional Relevant MeSH Terms

  • Nasolacrimal Duct Obstruction
  • Thyroid Cancer