RECRUITING

Therapeutic Ketogenic Diet in Anorexia Nervosa

Description

This study will investigate the effects of therapeutic ketogenic diet (TKD) on eating behavior including drive to restrict, body dissatisfaction, mood and anxiety in individuals with anorexia nervosa who have been weight normalized (body mass index of 17.5 or greater) but continue to struggle with eating disorder behaviors including a high drive for thinness and body dissatisfaction. The Underweight Anorexia Nervosa (AN) Sub-Study will investigate the effects of TKD on eating behavior including drive to restrict, body dissatisfaction, mood and anxiety in individuals with anorexia nervosa who are currently underweight (body mass index between 16.0 and 17.49) and continue to struggle with eating disorder behaviors including a high drive for thinness and body dissatisfaction. The Bulimia Nervosa Pilot will will investigate the effects of TKD on eating behavior including drive to binge and purge, body dissatisfaction, mood and anxiety in individuals with bulimia nervosa.

Conditions

Anorexia Nervosa in RemissionBulimia NervosaAnorexia Nervosa
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Related Conditions:

Anorexia Nervosa in RemissionBulimia NervosaAnorexia Nervosa

Study Overview

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Study Details

Study overview

This study will investigate the effects of therapeutic ketogenic diet (TKD) on eating behavior including drive to restrict, body dissatisfaction, mood and anxiety in individuals with anorexia nervosa who have been weight normalized (body mass index of 17.5 or greater) but continue to struggle with eating disorder behaviors including a high drive for thinness and body dissatisfaction. The Underweight Anorexia Nervosa (AN) Sub-Study will investigate the effects of TKD on eating behavior including drive to restrict, body dissatisfaction, mood and anxiety in individuals with anorexia nervosa who are currently underweight (body mass index between 16.0 and 17.49) and continue to struggle with eating disorder behaviors including a high drive for thinness and body dissatisfaction. The Bulimia Nervosa Pilot will will investigate the effects of TKD on eating behavior including drive to binge and purge, body dissatisfaction, mood and anxiety in individuals with bulimia nervosa.

Ketogenic Diet in Eating Disorders to Target Metabolism and Normalize Persistent Eating Disorder Psychopathology

Therapeutic Ketogenic Diet in Anorexia Nervosa

Condition
Anorexia Nervosa in Remission
Intervention / Treatment

-

Contacts and Locations

San Diego

University of California San Diego, San Diego, California, United States, 92121

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Provision of signed and dated informed consent form
  • 2. Stated willingness to comply with all study procedures and availability for the duration of the study
  • 3. Persons, aged 18 to 45 years
  • 4. History of anorexia nervosa according to DSM-5 criteria
  • 5. Weight recovered at the time of study inclusion (body mass index \> 17.5 kg/m2)
  • 6. Greater or equal to 2 standard deviations scores of eating disorder-relevant behaviors on the Eating Disorder Inventory-3 and Eating Disorder Examination Questionnaire
  • 7. The following types of psychiatric medications are allowed: antidepressant, anxiolytic, atypical antipsychotic, mood stabilizers
  • 8. English is primary spoken language
  • 1. Pregnancy or lactation
  • 2. Electrolyte, blood count, kidney function or liver function abnormalities
  • 3. Psychosis
  • 4. Neurocognitive disorders including dementias or traumatic brain injury that is symptomatic
  • 5. Current alcohol use disorder (AUD) or substance use disorder (SUD) according to DSM-5 criteria
  • 6. Uncontrolled hypertension
  • 7. Hepatic impairment (Class-Pugh b or c)
  • 8. Diabetes mellitus
  • 9. Family history of porphyria
  • 10. History of recent heart attack, vascular disease, or any other current acute medical conditions as determined by the principal investigator
  • 11. Inability or unwillingness to adhere to the TKD diet for the duration of the study
  • 12. Blind or illiterate individuals

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Guido Frank, MD, PRINCIPAL_INVESTIGATOR, University of California, San Diego

Study Record Dates

2027-06-30