Autoimmune and Autoinflammatory Genetics Study

Eligibility Criteria

• * Stated willingness to participate in study procedures (which at the very least includes providing a mail-in blood or saliva sample for genetic analysis);
• * Regardless of sex assigned at birth, at least one month of age;
• * A medical history that, in the expert opinion of the PI and study team, is consistent with the possibility of autoinflammatory disease or known diagnosis of an autoinflammatory disease, such as VEXAS syndrome; and
• * Ability of the subject, parents (in the case of children), or Legally Authorized Representative to understand and the willingness to sign a written informed consent document.
• * Stated willingness to participate in study procedures (which at the very least includes providing a mail-in sample for genetic analysis);
• * Regardless of sex assigned at birth, at least one month of age;
• * Relationship, either by blood or marriage, to an individual enrolled or about to be enrolled in the study with known or suspected autoinflammatory disease;
• * Likelihood, in the expert opinion of the PI and study team, that analysis of a sample from the individual would advance genetic or functional analysis of the affected relative's possible autoinflammatory condition; and
• * Ability of the subject, parents (in the case of children), to understand and the willingness to sign a written informed consent document.
• * Stated willingness to participate in study procedures for healthy volunteers;
• * Regardless of sex assigned at birth, at least five years old, and not pregnant (by history of a missed menstrual period);
• * Likelihood, in the expert opinion of the PI that a sample from the individual would advance the functional analysis of an autoinflammatory condition under study; and
• * Ability of the subject to understand and the willingness to sign a written informed consent document by a capacity assessment provided by the PI and study team.