RECRUITING

Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Delirium is an acute confusional state that is experienced by many older adults who are admitted to hospital. To treat delirium the underlying cause needs to be identified promptly, but this is challenging. One of the potential causes of delirium is infection. Urine tests show that most patients experiencing delirium have bacteria in their urine, however, bacteria in the urine is common among older adults, and does not automatically indicate an infection is present. As a result it is difficult to know whether a lower urinary tract infection is present as individuals with delirium are frequently unable to report clinical signs of infection - symptoms of pain or discomfort with urination, having to urinate more frequently or pelvic discomfort. Very often, individuals with delirium are treated with antibiotics despite the fact that it is unknown whether antibiotics help to improve delirium in cases where bacteria in the urine is present. This proposed study is a randomized controlled trial that will examine if adults (age 60 or older) with delirium and suspected infection benefit from taking antibiotics.

Official Title

Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection

Quick Facts

Study Start:2024-05-18
Study Completion:2027-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06004739

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Michael Fralick, MD
CONTACT
(416) 586-4800
mike.fralick@mail.utoronto.ca

Principal Investigator

Michael Fralick, MD, PhD
PRINCIPAL_INVESTIGATOR
Sinai Health System
Chris Kandel, MD, PhD
PRINCIPAL_INVESTIGATOR
Michael Garron Hospital
Nathan Stall, MD, PhD
PRINCIPAL_INVESTIGATOR
Sinai Health System

Study Locations (Sites)

Northwestern Memorial Hospital
Chicago, Illinois, 60611
United States

Collaborators and Investigators

Sponsor: Mount Sinai Hospital, Canada

  • Michael Fralick, MD, PhD, PRINCIPAL_INVESTIGATOR, Sinai Health System
  • Chris Kandel, MD, PhD, PRINCIPAL_INVESTIGATOR, Michael Garron Hospital
  • Nathan Stall, MD, PhD, PRINCIPAL_INVESTIGATOR, Sinai Health System

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-05-18
Study Completion Date2027-09

Study Record Updates

Study Start Date2024-05-18
Study Completion Date2027-09

Terms related to this study

Keywords Provided by Researchers

  • Delirium
  • Antibiotics
  • Older adults
  • Urinary Tract Infection

Additional Relevant MeSH Terms

  • Infectious Disease