Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

Description

This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.

Conditions

Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease, PreDiabetes

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Study Overview

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Study Details

Study overview

This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.

The Role of Circulating Meta-Inflammatory Monocytes in Adolescent Insulin Resistance

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

Condition
Type 2 Diabetes
Intervention / Treatment

-

Contacts and Locations

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Between 14 and 18 years of age
  • * Tanner stage 4 or 5 (mature adult stage of puberty)
  • * Normal weight (BMI ≥ 5th percentile \& \< 85th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c \> 5.7%)
  • * For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes
  • * Currently pregnant
  • * Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management
  • * Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff
  • * Allergies or intolerance to milk, soy, or palm oil

Ages Eligible for Study

14 Years to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Michigan,

Kanakadurga Singer, MA, MD, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

2027-09