RECRUITING

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.

Official Title

The Role of Circulating Meta-Inflammatory Monocytes in Adolescent Insulin Resistance

Quick Facts

Study Start:2023-09-06
Study Completion:2027-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06007404

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:14 Years to 18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Between 14 and 18 years of age
  2. * Tanner stage 4 or 5 (mature adult stage of puberty)
  3. * Normal weight (BMI ≥ 5th percentile \& \< 85th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c \> 5.7%)
  4. * For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes
  1. * Currently pregnant
  2. * Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management
  3. * Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff
  4. * Allergies or intolerance to milk, soy, or palm oil

Contacts and Locations

Study Contact

The Singer Lab Team
CONTACT
(734) 615-4938
MiMoStudy@med.umich.edu

Principal Investigator

Kanakadurga Singer, MA, MD
PRINCIPAL_INVESTIGATOR
University of Michigan

Study Locations (Sites)

University of Michigan
Ann Arbor, Michigan, 48109
United States

Collaborators and Investigators

Sponsor: University of Michigan

  • Kanakadurga Singer, MA, MD, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-09-06
Study Completion Date2027-09

Study Record Updates

Study Start Date2023-09-06
Study Completion Date2027-09

Terms related to this study

Additional Relevant MeSH Terms

  • Type 2 Diabetes
  • Insulin Resistance
  • Obesity
  • Metabolic Disease
  • PreDiabetes