RECRUITING

Non-invasive Brain Stimulation to Improve Unsteady Gait in Older Adults (StimGait)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Walking is a complex and continuous task that entails repetitive motions of the body. Relatively high gait variability sensitively predicts falls and cognitive decline in older adults. Previous work has identified an unique brain network relationship linked to gait variability and its relevant cognitive function (i.e., sustained attention). This project aims to develop a non-invasive brain stimulation montage designed to modulate the shared brain networks dynamics and to demonstrate its effects on resting state functional connectivity, gait and cognitive performance in older adults at risk for falls.

Official Title

Modulating Brain Networks to Reduce Gait Variability in Older Adults at Risk of Falling

Quick Facts

Study Start:2024-06-03
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06008431

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Aged 65 and above.
  2. * Ability to speak and read English.
  3. * Ability to walk independently and continuously for at least 1 minute.
  4. * Elevated gait variability as defined by a coefficient of variation (CoV) about average stride time larger and equal to 0.025 during straight-line walking at preferred speed.
  1. * More than mild cognitive impairment defined by a Montreal Cognitive Assessment (MoCA) score less than 18.
  2. * Parkinson's disease, multiple sclerosis, stroke, active brain tumor, or other neurological disorders.
  3. * Self-reported pain or lower extremity deformity that significantly disrupts walking.
  4. * Contraindications to MRI or tDCS.
  5. * An episode of acute illness or exacerbation of a diagnosis that requires hospitalization or active treatment within the past 3 months.
  6. * Current treatment for congestive heart failure, angina, uncontrolled arrythmia, deep vein thrombosis, or other uncontrolled cardiovascular events.
  7. * Myocardial infarction, coronary artery bypass grafting, angioplasty, or other cardiac conditions within the past 3 months,
  8. * Active cancer for which chemo/radiation therapy is being received.
  9. * Psychiatric co-morbidity including major depressive disorder, schizophrenia, psychosis, or other psychiatric illness.
  10. * Recent use of any sedating medications (sedatives, anti-psychotics, hypnotics, anti-depressants) or change in medication within the previous month.
  11. * Chronic vertigo or other diagnosed vestibular disorders.
  12. * Legal blindness, visual impairments that cannot be corrected with glasses, contact lenses, medicine, or surgery.
  13. * Those without WiFi access
  14. * Those who do not plan to live in their current homes for the duration of the study

Contacts and Locations

Study Contact

On-Yee Lo, Ph.D.
CONTACT
617-931-5331
AmyLo@hsl.harvard.edu

Principal Investigator

On-Yee Lo, Ph.D.
PRINCIPAL_INVESTIGATOR
Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife

Study Locations (Sites)

Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife
Boston, Massachusetts, 02131
United States

Collaborators and Investigators

Sponsor: Hebrew SeniorLife

  • On-Yee Lo, Ph.D., PRINCIPAL_INVESTIGATOR, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-03
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2024-06-03
Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

  • transcranial direct current stimulation (tDCS)
  • transcranial electrical stimulation (tES)
  • Non-invasive brain stimulation (NIBS)
  • Falls
  • Gait Variability
  • Sustained Attention
  • Dorsal Attention Network
  • Default Network

Additional Relevant MeSH Terms

  • Fall
  • Gait, Unsteady
  • Mobility Limitation