Maternal Brain Imaging in Opioid Use Disorder

Description

This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved. During pregnancy, people with OUD are prescribed medication-assisted therapy (MAT). The investigators are interested to know how the medication is broken down by the body during pregnancy and how effective it is. The investigators also want to learn if this medication and OUD have any effect on the different parts of the brain when compared to mothers without OUD.

Conditions

Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related, Narcotic-Related Disorders, Buprenorphine Dependence

Study Overview

Study Details

Study overview

This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved. During pregnancy, people with OUD are prescribed medication-assisted therapy (MAT). The investigators are interested to know how the medication is broken down by the body during pregnancy and how effective it is. The investigators also want to learn if this medication and OUD have any effect on the different parts of the brain when compared to mothers without OUD.

Maternal Brain Imaging in Opioid Use Disorder

Maternal Brain Imaging in Opioid Use Disorder

Condition
Opioid Use Disorder
Intervention / Treatment

-

Contacts and Locations

Indianapolis

Riley Hospital for Children, Indianapolis, Indiana, United States, 46202

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age: \>18 years old
  • * Any subject that is currently on Buprenorphine at time of screening
  • * Singleton pregnancy
  • * Serious maternal medical illness
  • * HIV or AIDs
  • * Polysubstance use
  • * Score \>9 on the PHQ-9, and score \>0 on item 9 which is about suicidality
  • * Score of 8 or more on GAD-7
  • * Any contraindications for MRI
  • * Known or suspected major fetal congenital abnormalities
  • * Age: \>18 years old
  • * Singleton pregnancy
  • * Serious maternal medical illness
  • * HIV or AIDS
  • * Score of \>9 on the PHQ-9, and a score of \>0 on item 9 which is about suicidality
  • * Score of 8 or more on GAD-7
  • * Known or suspected major fetal congenital abnormalities
  • * Any contraindications for MRI
  • * Opioid or polysubstance abuse as identified on urine screening

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Indiana University,

Study Record Dates

2025-07-31