Internet-Based Lifestyle Intervention (iLIVE) to Eradicate Obese Frailty in Prostate Cancer Survivors

Description

This clinical trial tests the effectiveness of an online weight loss plus resistance training intervention (iLIVE) to decrease obesity and improve frailty in men with prostate cancer who received androgen deprivation therapy (ADT). Androgen deprivation therapy increases the risk of frailty, weight gain and obesity in prostate cancer survivors. The combination of frailty and obesity can lead to a decrease in quality of life and an increased risk of recurrent falls. Using iLIVE may improve obesity and frailty in men with prostate cancer who receive ADT.

Conditions

Prostate Carcinoma

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Study Overview

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Study Details

Study overview

This clinical trial tests the effectiveness of an online weight loss plus resistance training intervention (iLIVE) to decrease obesity and improve frailty in men with prostate cancer who received androgen deprivation therapy (ADT). Androgen deprivation therapy increases the risk of frailty, weight gain and obesity in prostate cancer survivors. The combination of frailty and obesity can lead to a decrease in quality of life and an increased risk of recurrent falls. Using iLIVE may improve obesity and frailty in men with prostate cancer who receive ADT.

Internet-Based Lifestyle Intervention to Eradicate Obese Frailty in Prostate Cancer Survivors (iLIVE)

Internet-Based Lifestyle Intervention (iLIVE) to Eradicate Obese Frailty in Prostate Cancer Survivors

Condition
Prostate Carcinoma
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama, Birmingham, Alabama, United States, 35294

Portland

OHSU Knight Cancer Institute, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * INTERVENTION PARTICIPANTS: Age 18 or older
  • * INTERVENTION PARTICIPANTS: Diagnosed with histologically confirmed prostate cancer
  • * INTERVENTION PARTICIPANTS: Received \>= 6 months of ADT any time in the past 10 years
  • * INTERVENTION PARTICIPANTS: Completed radiotherapy, chemotherapy and/or surgery \> 6 weeks prior to
  • * INTERVENTION PARTICIPANTS: No intent to start adjuvant chemotherapy or radiotherapy within 6 months of enrollment
  • * INTERVENTION PARTICIPANTS: Overweight or obese (BMI \> 25 kg/m2 to BMI ≤ 50).
  • * INTERVENTION PARTICIPANTS: Evidence of frailty by meeting three or more of the following frailty criteria: weakness, slowness, fatigue, inactivity, and/or illness
  • * INTERVENTION PARTICIPANTS: Not currently engaging in structured diet or resistance strength training exercise program
  • * INTERVENTION PARTICIPANTS: Willing to be randomized into either study arm and adhere to study protocol
  • * INTERVENTION PARTICIPANTS: Home internet sufficient for videoconferencing
  • * INTERVENTION PARTICIPANTS: Signed informed consent
  • * IMPLEMENTATION PARTICIPANTS: Be a key stakeholder (i.e., healthcare provider or administrative, or intervention participant \[completers, partial completers, or no participation\])
  • * IMPLEMENTATION PARTICIPANTS: Verbal informed consent following receipt of an information sheet
  • * INTERVENTION PARTICIPANTS: Unintentional weight loss \> 5% within the last year
  • * INTERVENTION PARTICIPANTS: Contraindication to moderate intensity exercise
  • * INTERVENTION PARTICIPANTS: Health or medical condition that affects weight status/body composition (e.g., Cushing's syndrome, uncontrolled hyper-/hypo- thyroidism)
  • * INTERVENTION PARTICIPANTS: Active malignancy (other than non-melanoma skin cancer)
  • * INTERVENTION PARTICIPANTS: Not fluent in English and therefore incapable of answer survey questions, following directions during exercise or performance testing, and providing informed consent in English

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

OHSU Knight Cancer Institute,

Kerri Winters-Stone, PRINCIPAL_INVESTIGATOR, OHSU Knight Cancer Institute

Study Record Dates

2027-12-31