P-CD19CD20-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With B Cell Malignancies

Description

Phase 1 study comprised of open-label, dose escalation and expansion cohort study of P-CD19CD20-ALLO1 allogeneic T stem cell memory (Tscm) CAR-T cells in subjects with relapsed/refractory B cell malignancies

Conditions

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High-grade B-cell Lymphoma, Primary Mediastinal Large B-cell Lymphoma (PMBCL), Transformed Follicular Lymphoma (tFL), Follicular Lymphoma Grade 3B

Study Overview

Study Details

Study overview

Phase 1 study comprised of open-label, dose escalation and expansion cohort study of P-CD19CD20-ALLO1 allogeneic T stem cell memory (Tscm) CAR-T cells in subjects with relapsed/refractory B cell malignancies

Open-Label, Multicenter, Phase 1 Study to Assess the Safety of P-CD19CD20-ALLO1 in Subjects With Selected Relapsed/Refractory B Cell Malignancies

P-CD19CD20-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With B Cell Malignancies

Condition
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Intervention / Treatment

-

Contacts and Locations

La Jolla

University of California San Diego, La Jolla, California, United States, 92093

Loma Linda

Loma Linda University Cancer Center, Loma Linda, California, United States, 92354

Detroit

Wayne State - Karmanos Cancer Institute, Detroit, Michigan, United States, 48201

Chapel Hill

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States, 27599

Cincinnati

University of Cincinnati, Cincinnati, Ohio, United States, 45206

Oklahoma City

University of Oklahoma, Health Sciences Center, Oklahoma City, Oklahoma, United States, 73104

Greenville

Prisma Health - Upstate Cancer Institute, Greenville, South Carolina, United States, 29605

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Dallas

Baylor Scott & White Research Institute, Dallas, Texas, United States, 75204

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Poseida Therapeutics, Inc.,

    Rajesh Belani, MD, STUDY_DIRECTOR, Vice President, Clinical Development

    Study Record Dates

    2041-03