There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.
Diastolic Heart Failure, Heart Failure With Preserved Ejection Fraction
There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.
Purinergic Signaling and the Postmenopausal Heart
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Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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30 Years to 88 Years
ALL
No
Beth Israel Deaconess Medical Center,
Robina Matyal, MD, PRINCIPAL_INVESTIGATOR, Beth Israel Deaconess Medical Center, Professor of Anesthesia
Simon Robson, MD, PhD, PRINCIPAL_INVESTIGATOR, Beth Israel Deaconess Medical Center,Vice Chair Research
2025-06